Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Mercury ions (Hg2+) have been found to disrupt the body's antioxidant defense mechanisms, leading oxidative stress and physiological dysfunction. Early diagnosis real-time monitoring of Hg2+ fluctuations in organ damage are crucial but limited due lack noninvasive deep tissue imaging probes. Herein, a Hg2+-triggered targeted NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for Hg2+-induced acute liver kidney injury mice. NHG-2 designed through rational adjustment conjugated ring structure further screening processes, enabling it sensitively recognize subsequently open mitochondrial targeting, producing fluorescence/PA signals. This allowed injury, demonstrating excellent detection sensitivity. Furthermore, can be utilized evaluate efficacy N-acetylcysteine (NAC) dual signal indication. Mechanism studies suggested that NAC activated Akt/Nrf2 signaling pathway, reversed changes related biomarkers, restored membrane potential. Thus, this study not only presents first specific also provides potential tool early treatment evaluation pathogenesis study.

Language: Английский

Physicochemical characterization, release profile, and antibacterial mechanisms of caffeic acid phenethyl ester loaded in lipid nanocapsules with lauric acid and glycerol monolaurate

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116208 - 116208

Published: March 1, 2025

Language: Английский

Carboxymethyl chitosan-enhanced multi-level microstructured composite hydrogel scaffolds for bone defect repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122847 - 122847

Published: Oct. 14, 2024

Language: Английский