Amine-Rich Carbon Dots Synthesized from Kappa-Carrageenan and l-Lysine as a Dual Probe for Detection of Folic Acid and Tumor-Targeted Delivery of Therapeutics

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 6034 - 6043

Published: Aug. 24, 2024

Strategically designed, heteroatom-rich surface functionalized blue fluorescent carbon dots (CDs) were synthesized for high-throughput detection of folic acid (vitamin B9). The highly stable CDs could particularly detect vitamin B9 in the presence 35 analytes, even up to 40 nM vitamin. versatile found have a high affinity wastewater, tablets, and food samples enriched with acid. hemocompatibility was also studied by using hemolysis assay, confirming be nontoxic human blood 400 μg/mL. then covalently conjugated biotin, which possesses receptors that are overexpressed tumor cells. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide dye) assay confocal bioimaging studies proved biotin-modified (CDBT) remarkably healthy cell lines (HEK-293) target-specific toward cells (HeLa), including triple-negative breast cancer (MDA-MB-231). cytotoxicity 5-fluorouracil encapsulated (CDBTFu) showed IC

Language: Английский

Carbon Dots from Pre‐Existing Nanoparticles Versus Carbonization: Similarity and Difference in Sample Structure‐Morphology with Property and Mechanistic Consequences

Small Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Carbon dots (CDots) are classically synthesized by organic functionalization of pre‐existing small carbon nanoparticles, but most the dot samples reported in literature prepared thermal carbonization processing selected precursors. Highlighted and discussed this article necessity using proper conditions for produced to be CDots like, similarities differences sample structure morphology between two kinds samples, their associated property mechanistic consequences.

Language: Английский