Green-synthesized silver nanoparticles from peel extract of pumpkin as a potent radiosensitizer against triple-negative breast cancer (TNBC)
Cancer Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 21, 2024
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
of
cancer.
Radiation
therapy
(RT)
a
modality
for
TNBC
management.
Radiosensitizers
can
mitigate
the
adverse
effects
RT.
Applying
green-synthesized
silver
nanoparticles
(Ag-NPs)
from
biological
sources
such
as
plants
potential
strategy
to
sensitize
cells
radiotherapy
due
low
toxicity.
Therefore,
identifying
novel
natural
synthesizing
stable
and
broadly
applicable
green-Ag-NPs
has
gained
more
attention
in
therapy.
In
present
study,
we
synthesized
green-
Ag-NPs
pumpkin
peel
extract
elucidated
impact
radiosensitizer
MDA-MB
231
(a
model
TNBC).
The
prepared
had
spherical
shape
with
average
size
81
nm
zeta
−
9.96
mV.
Combination
RT
exhibited
synergistic
anticancer
optimum
combination
index
(CI)
0.49
MDA-MB-231
cells.
Green-synthesized
synergistically
potentiated
RT-induced
apoptosis
compared
corresponding
monotherapies.
Morphological
features
were
further
confirmed
by
DAPI–TUNEL
staining
assay.
HIF-1α
expression
was
decreased
subjected
Bax
p53
increased,
whereas
Bcl-2
genes
decreased.
significantly
increased
protein
level
PERK
CHOP
while
decreasing
cyclin
D1
p-ERK/total
ERK
levels
These
findings
indicate
effect
treatment.
Language: Английский
A comparative study of in vivo toxicity in zebrafish embryos synthesized CuO nanoparticles characterized from Salacia reticulata
Environmental Geochemistry and Health,
Journal Year:
2024,
Volume and Issue:
46(9)
Published: July 13, 2024
Language: Английский
Antihyperglycemic Activity of Polyphenolic Metabolites and Biosynthesized Silver Nanoparticles from Pedalium murex: Characterization and Application of Antioxidant and Uropathogenic Antimicrobial Activities
Microbial Pathogenesis,
Journal Year:
2025,
Volume and Issue:
205, P. 107620 - 107620
Published: April 24, 2025
Language: Английский
Green synthesis of silver NPs using aqueous extract of Artemisia scoparia for hydrogenation of aromatic nitro compounds and their biological activity
Praveesh Bhati,
No information about this author
Richa Tiwari,
No information about this author
S. L. Kothari
No information about this author
et al.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 25, 2025
The
green
synthesis
of
silver
nanoparticles
(AgNPs)
using
Artemisia
scoparia
(
A.
),
a
plant
abundant
in
bioactive
compounds,
provides
an
eco-friendly,
cost-effective,
and
sustainable
method
for
nanoparticle
synthesis.
Silver
ions
were
successfully
reduced
aqueous
extract
,
resulting
AgNPs
with
characteristic
UV–visible
absorption
peak
at
421
nm.
Comprehensive
characterization
FTIR,
TEM,
SEM,
DLS
confirmed
their
stability,
uniform
morphology,
functional
groups.
antibacterial
activity
the
synthesized
was
evaluated
against
E.
faecalis
P.
aeruginosa
catalytic
assessed
by
reducing
aromatic
nitro
compounds.
-derived
demonstrated
potent
activity,
effectively
inhibiting
growth
indicating
potential
addressing
antibiotic-resistant
bacteria.
Additionally,
these
exhibited
remarkable
efficiency
showcasing
as
eco-friendly
catalysts.
This
dual
functionality
highlights
significant
role
nanotechnology
environmental
remediation
efforts.
Language: Английский
Fabrication of Highly Stable Polyurushiol-Decorated Silver Nanoparticles and Evaluation of Their Antibacterial and Anti-Microalgae Activities
Lu Zheng,
No information about this author
Jide Zhu,
No information about this author
Jipeng Chen
No information about this author
et al.
Journal of Inorganic and Organometallic Polymers and Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 7, 2024
Language: Английский
Biosynthesis of ZnO nanocomposites from Mentha spicata applications of antioxidant, antimicrobial and genotoxicity advances in MCF-7 cell line
Sensing and Bio-Sensing Research,
Journal Year:
2024,
Volume and Issue:
46, P. 100707 - 100707
Published: Nov. 1, 2024
Language: Английский
Biochemical Characterization and Green Synthesis of Silver Nanoparticles (AgNPs) from Costus spicatus for Potential Anti-Diabetic Target in Streptozocin (STZ) Induced Diabetic Rats
Journal of Inorganic and Organometallic Polymers and Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Language: Английский
Identification of Bio-Active Compounds and Biochemical Characterization of Green Synthesized of Silver Nanoparticles (AgNPs) against Selected Uropathogenic Antimicrobial Activity
Journal of Inorganic and Organometallic Polymers and Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Language: Английский