Cationic Micelle-like Nanoparticles as the Carrier of Methotrexate for Glioblastoma Treatment DOI Creative Commons
Tuğba Nur Aslan

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5977 - 5977

Published: Dec. 18, 2024

In the present study, ultra-small, magnetic, oleyl amine-coated Fe3O4 nanoparticles were synthesized and stabilized with a cationic ligand, cetyltrimethylammonium bromide, an anticancer drug, methotrexate, was incorporated into micelle-like nanoparticle structure for glioblastoma treatment. Nanoparticles further characterized their physicochemical properties using spectroscopic methods. Drug incorporation efficiency, drug loading, release profile of investigated. According to results, max efficiency% 89.5 found 25 µg/mL methotrexate-loaded nanoparticles. The cumulative amount methotrexate released reached 40% at physiological pH 85% 5.0 up 12 h. toxicity efficacy also studied on U87 cancer L929 cells. IC50 concentration reduced cell viability 49% in 72% cellular uptake be 1.92-fold higher than total apoptosis% cells estimated ~10-fold what observed inhibited motility prevented metastasis lines. Overall, designed are promising controlled delivery system achieve better therapeutic outcomes.

Language: Английский

Green Fe3O4 nanozymes for cancer Detection, H2O2 sensing and ROS-Mediated apoptosis DOI
Tuğba Nur Aslan

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113643 - 113643

Published: April 1, 2025

Language: Английский

Citations

0
Gd (III) complex supported functionalized magnetic mesoporous silica particles as an efficient and recoverable novel catalyst in the synthesis of 5-substituted 1H-tetrazoles in green media DOI
Somayeh Molaei, Mohammad Ghadermazi

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

Citations

0
Cationic Micelle-like Nanoparticles as the Carrier of Methotrexate for Glioblastoma Treatment DOI Creative Commons
Tuğba Nur Aslan

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5977 - 5977

Published: Dec. 18, 2024

In the present study, ultra-small, magnetic, oleyl amine-coated Fe3O4 nanoparticles were synthesized and stabilized with a cationic ligand, cetyltrimethylammonium bromide, an anticancer drug, methotrexate, was incorporated into micelle-like nanoparticle structure for glioblastoma treatment. Nanoparticles further characterized their physicochemical properties using spectroscopic methods. Drug incorporation efficiency, drug loading, release profile of investigated. According to results, max efficiency% 89.5 found 25 µg/mL methotrexate-loaded nanoparticles. The cumulative amount methotrexate released reached 40% at physiological pH 85% 5.0 up 12 h. toxicity efficacy also studied on U87 cancer L929 cells. IC50 concentration reduced cell viability 49% in 72% cellular uptake be 1.92-fold higher than total apoptosis% cells estimated ~10-fold what observed inhibited motility prevented metastasis lines. Overall, designed are promising controlled delivery system achieve better therapeutic outcomes.

Language: Английский

Citations

2