Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 194 - 194
Published: Feb. 4, 2025
Background:
The
skin
represents
the
first
barrier
of
defense,
and
its
integrity
is
crucial
for
overall
health.
Skin
wounds
present
a
considerable
risk
seeing
how
their
progression
rapid
sometimes
they
are
caused
by
comorbidities
like
diabetes
venous
diseases.
Nutraceutical
combinations
ones
between
polyphenols
metal
ions
applications
thanks
to
increased
bioavailability
ability
modulate
intrinsic
molecular
pathways.
Methods:
research
findings
presented
in
this
paper
based
on
systematic
review
current
literature
with
an
emphasis
nanotechnology
regenerative
medicine
strategies
that
incorporate
metallic
nanoparticles
(NPs).
key
studies
which
described
action
mechanisms,
efficacy,
safety
these
hybrid
formulations
were
reviewed.
Results:
Nanocomposites
polyphenol
promote
healing
activating
signaling
pathways
such
as
PI3K/Akt
ERK1/2,
turn
improve
fibroblast
migration
proliferation.
Nanoparticles
silver
copper
have
antibacterial,
angiogenesis-promoting,
inflammation-modulating
capabilities.
With
induce
apoptosis
restrict
cell
growth,
composites
potential
cure
malignancies
addition
facilitating
wound
healing.
Conclusions:
metals
provide
hope
treatment
cancer
chronic
wounds.
Their
antimicrobial
capabilities,
capacity
inflammatory
responses,
enhancement
activity
all
point
medicinal
potential.
Furthermore,
decrease
inflammation
associated
tumors
while
simultaneously
inducing
death
cells.
Clarifying
guaranteeing
stability,
enhancing
effective
delivery
techniques
clinical
usage
should
be
focus
future
studies.
Language: Английский
Copper- and Iron-Based Nanoflowers in Cancer Theranostics
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(23), P. 11294 - 11294
Published: Dec. 4, 2024
In
recent
years,
nanoscience
and
nanotechnology
have
gained
prominence
within
materials
science,
offering
new
opportunities
for
cancer
diagnosis
treatment.
Advances
in
allowed
the
manipulation
size
control
of
nanomaterials,
leading
to
development
a
wide
range
materials.
The
use
nanomaterials
as
chemical
biology
tools
theranostics
has
been
widely
investigated,
owing
their
enhanced
stability,
biocompatibility,
improved
cell
permeability.
These
properties
enable
precise
targeting
while
addressing
limitations
conventional
treatments.
Nanoflowers,
specific
class
recently
attracted
significant
interest
due
promising
several
biomedical
applications.
However,
despite
growing
attention
toward
nanoflowers,
detailed
reviews
on
subject
limited.
This
work
focuses
two
primary
types
hybrid
nanoflowers:
iron-
copper-based
ones.
Within
this
article
an
overview
applications
are
thoroughly
reviewed,
synthesis
processes
controlling
morphology
size,
underlying
functions,
characteristics
uses
also
extensively
explored,
aiming
provide
guide
future
developments
field.
Language: Английский