Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock DOI Creative Commons
Gongsheng Yuan

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 705 - 705

Published: March 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Language: Английский

Basic research on circadian disruption using animal and human organoid models: a review DOI
Hamideh Rahmati, Behzad Garmabi, Hamed Ghazvini

et al.

Biological Rhythm Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 1, 2025

Language: Английский

Citations

0
Time matters: chrono-pharmacotherapy as precision medicine DOI Creative Commons

Samir Arabi,

Sajjad Ahmad

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

The circadian clock and its inherent rhythms serve as the foundation for regulating many of body’s vital processes. Recent advances in medicine have leveraged these natural cycles through chronotherapy, practice timing drug administration to align with body's internal clock, enhance treatment outcomes. Endogenous clocks not only dictate physiological but also influence how drugs are absorbed, distributed, metabolized, excreted, thereby affecting both their therapeutic efficacy potential toxicity. When disrupted, resulting imbalance has been linked a range disorders, such cancer cardiovascular diseases, highlighting growing need time-sensitive strategies. Technological breakthroughs, including wearable sensors, digital health platforms, sophisticated machine learning techniques, now allow continuous, real-time monitoring biomarkers, which turn helps optimize regimens. In oncology, example, synchronizing chemotherapy, therapy, immunotherapy anti-inflammatory patient’s cycle shown effectiveness improve tolerability. Moreover, observed sex-based differences responses emphasize importance tailoring individual patient profiles. Emerging research is focusing on directly targeting molecular components, showing treating metabolic oncological conditions. However, fully integrating chronopharmacology into clinical will require development standardized protocols, regulatory backing, large-scale trials that incorporate biomarkers. Ultimately, merging biology strategies promises efficacy, minimize side effects, Future studies must address inter-individual variability, sex differences, misalignment harness chronotherapy’s personalized medicine.

Language: Английский

Citations

0
The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity DOI Creative Commons
Sajal Kumar Halder, Girish C. Melkani

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 1, 2025

Abstract Purpose of Review This review explores the complex interplay between genetic predispositions to obesity, circadian rhythms, metabolic regulation, and sleep. It highlights how factors underlying obesity exacerbate dysfunction through misalignment examines promising interventions mitigate these effects. Recent Findings Genome-wide association Studies (GWAS) have identified numerous Single Nucleotide Polymorphisms (SNPs) associated with traits, attributing 40–75% heritability body mass index (BMI). These findings illuminate critical links clocks, processes. SNPs in clock-related genes influence pathways, disruptions rhythms—driven by poor sleep hygiene or erratic eating patterns—amplifying dysfunction. Circadian synchronized 24-h light–dark cycle, regulate key activities, including glucose metabolism, lipid storage, energy utilization. Genetic mutations external disruptions, such as irregular habits, can destabilize promoting weight gain disorders. Summary individuals disrupts release hormones, leptin insulin, impairing hunger regulation fat storage. Interventions like time-restricted feeding (TRF) structured physical activity offer strategies restore harmony, improve health, obesity-related risks.

Language: Английский

Citations

0
Chronotherapeutic considerations of benzodiazepine administration for agitation management in the emergency department DOI Creative Commons

Emily Rudisell,

Kyle A. Weant, Alessandra Porcu

et al.

BMJ Mental Health, Journal Year: 2025, Volume and Issue: 28(1), P. e301189 - e301189

Published: March 1, 2025

Objective Agitation in the emergency department (ED) affects up to 2.6% of encounters, posing significant risks patients and caregivers. This review investigates impact circadian rhythms on benzodiazepine (BZD) pharmacokinetics pharmacodynamics, focusing how dosing time influences outcomes managing acute agitation. Methods A comprehensive literature search was performed using PubMed Google Scholar (updated April 2024) identify studies BZD use adult ED for Search terms included “antipsychotic agents,” “lorazepam,” “midazolam,” “diazepam,” “emergency service.” Studies solely substance intoxication were excluded. Priority given double-blind clinical trials, while open-label if no data available. Referenced citations from identified publications also reviewed. Results Twenty-nine met inclusion criteria: 16 randomised, double-blinded placebo-controlled 5 prospective 8 retrospective reviews. Of these, 22 either did not report day patient recruitment or recruited over a year-long frame. Four that specified suggested possible variation sedation efficacy. Additionally, three reported months revealed potential seasonal patterns requirements Conclusions Circadian appear influence metabolism therapeutic effects, which could have implications optimising treatment strategies. Aligning schemes with biological timing may enhance minimise adverse effects. Further research is needed validate these findings develop personalised chronopharmacotherapy strategies agitation ED.

Language: Английский

Citations

0
Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock DOI Creative Commons
Gongsheng Yuan

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 705 - 705

Published: March 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Language: Английский

Citations

0