Evaluation of Antibacterial, Antioxidant, and Anticataleptic Activity on Methanol Seed Extract of <i>Cannabis sativa</i>: An <i>In Vitro</i> and <i>In Vivo</i> Study DOI Open Access

Dasaprakash Annadurai,

Kavita Raj,

M. Francis

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2713 - 2725

Published: Dec. 31, 2024

Background: Cannabis sativa (CS) has been traditionally used for its medicinal properties, including antioxidant, antibacterial, and neuroprotective effects. However, potential anticataleptic activity remains unexplored. Aim: This study aimed to investigate the qualitative phytochemical analysis, of methanolic seed extract (CSCME). Methods: The antioxidant CSCME was evaluated using DPPH radical scavenging assay. Antibacterial properties were assessed agar well diffusion method. For study, Wistar albino rats (n=30) divided into five groups: control, disease control (haloperidol 1mg/kg), standard treatment 1mg/kg + trihexyphenidyl two groups receiving haloperidol with (10mg/kg 20mg/kg). Treatments administered daily 15 days, catalepsy severity block metal bar methods. Results: exhibited significant antibacterial comparable commercial drugs. In vivo, results showed a reduction in cataleptic scores (P<0.05) compared control. Notably, 20mg/kg group demonstrated similar reductions as (P>0.05). Conclusion: demonstrates that possesses activities, suggesting therapeutic agent managing other neurological disorders. findings warrant further investigation clinical applications CSCME.

Language: Английский

Upcycling of polyethylene terephthalate (PET) plastic wastes into carbon-based nanomaterials: Current status and future perspectives DOI

Vatika Soni,

Duc Anh Dinh, Komal Poonia

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 215, P. 113249 - 113249

Published: June 21, 2024

Language: Английский

Citations

10
Synergistic impacts of novel tantalum doping in BiVO4 for effective photocatalytic applications, antimicrobial activity, and antioxidant aspect DOI
Tahir Iqbal, Muhammad Tauseef Qureshi, Raheem Shahzad

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 170, P. 113365 - 113365

Published: Oct. 24, 2024

Language: Английский

Citations

4
Innovative Nano Delivery Systems for Astaxanthin: Enhancing Stability, Bioavailability, and Targeted Therapeutic Applications DOI

Lei Jia,

Wei Wang, Hongyu Zhao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(6), P. 3286 - 3304

Published: Jan. 31, 2025

Astaxanthin (AST), as a natural antioxidant, has broad application prospects in medicine and health products. However, its highly unsaturated structure significant lipophilic characteristics limit dispersibility bioavailability, thereby restricting food, medicines, nutraceuticals. To overcome these limitations, researchers have proposed the use of nano delivery systems. This review summarizes various nanocarriers, including liposomes, nanostructured lipid carriers, nanoparticles, others, analyzes their advantages enhancing solubility, stability, bioavailability AST. Furthermore, study focuses on targeted systems achieved through biomolecular modifications, which enable precise AST to specific cells or tissues, therapeutic effects. Additionally, smart-responsive systems, such pH-responsive light-sensitive are also discussed, showing immense potential release therapy. These findings provide new perspectives for nutrition clinical applications Future research should further optimize design nanocarriers broader applications.

Language: Английский

Citations

0
Unraveling the photocatalytic degradation of pantoprazole antibiotics using eco-friendly synthesized CeVO4 nanoparticles DOI

Kajalben Patel,

Yogita Abhale,

Soumya Ranjan Mishra

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114534 - 114534

Published: April 1, 2025

Language: Английский

Citations

0
Applications of CeO2-based heterojunctions in photocatalytic bactericidal and antitumor therapy DOI
Chengzhang Zhu,

Qihang Tian,

Binghan Wang

et al.

Journal of Rare Earths, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

2
Green Synthesis of Multifunctional CdS Nanoparticles from Cinnamon (Cinnamomum verum) Extract-Functionalized for In Vitro Biomedical, Photocatalytic Degradation and Photoelectrochemical Applications DOI

Komal V. R. Jarhad,

Aniket A. Pawanoji,

Pranali S. Parab

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 28, 2024

Language: Английский

Citations

2
Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum DOI
Mukul Machhindra Barwant,

Vanita Karande,

Parita Basnet

et al.

Journal of Sol-Gel Science and Technology, Journal Year: 2024, Volume and Issue: 111(2), P. 409 - 420

Published: June 24, 2024

Language: Английский

Citations

1
Evaluation of Antioxidant, Antibacterial and Antidiabetic Activity of <i>Juglans regia</i> Root Extract: <i>In Vitro</i> and <i>In Vivo</i> Studies DOI Open Access

M. Francis,

S Padmaja,

Arunkumar Radhakrishnan

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2263 - 2275

Published: Nov. 6, 2024

Background: Diabetes mellitus is a long-term metabolic illness that occurs due to malfunction in the production or action of insulin. Prolonged hyperglycemia may lead dysfunction and failure several organs, such as diabetic nephropathy, retinopathy neuropathy. The incidence diabetes number patients has consistently risen over last decades. Juglans regia, member Juglandaceae family, been used by practitioners folklore treat illnesses. Aim: To Evaluate antioxidant anti-bacterial effects root extract from regia vitro studies anti-diabetic effect Streptozotocin (STZ) induced Wistar albino rats. Methods: Qualitative phytochemical analysis, assay were done using DPPH, antibacterial have performed agar well diffusion method tested inducing rats with STZ followed administering methanolic alone adjuvants metformin glipalamide. Result: can decrease free radicals, possess property in-vivo group 2 (diabetic control) showed elevated FBS HbA1C day 3 28 while 3, 4, 5, 6, 7 8 significant reduction levels at end study. Safety profiles CBC, RFT LFT did not show any difference between groups baseline Thus, was safe efficacious against Conclusion: reduce be an adjuvant Metformin Glibenclamide. Also, it possesses anti-oxidant activity studies.

Language: Английский

Citations

1
Evaluating the Antioxidant and Anticancer Activity of <i>Saccharum spontaneum</i> Linn Flower Extract in Hepatocellular Carcinoma: An <i>In Vitro</i> and <i>In Vivo</i> Study DOI Open Access

Caroline Sindhu Paulraj,

Gowtham Kumar Subbaraj,

J Arifunhera

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2493 - 2503

Published: Dec. 5, 2024

Background: Advanced Hepatocellular Carcinoma (HCC) is a devastating disease with poor survival rate, emphasising the urgent need for novel and effective therapeutic agents. Saccharumspontaneum Linn (S. spon), member of Poaceae family, has garnered attention due to its diverse pharmacological benefits, including antibacterial, antioxidant anti-inflammatory properties. Aim: This study aims investigate phytochemical composition S. spon flower extract evaluate anticancer potential against HCC. Methods: The activity Methanolic Extract (ME) flowers was assessed using DPPH Ferric Reducing Antioxidant Power (FRAP) assays. efficacy evaluated MTT assay on HepG2 cell lines. An in vivo also conducted diethyl nitrosamine-induced hepatocellular carcinoma animal model. Results: results showed significant FRAP revealed dose- time-dependent decrease viability, an IC50 value 25.5 µM/mL. Furthermore, ME exhibited notable cytotoxic effects mitigated liver injury model, as evidenced by decreased enzyme levels (p < 0.05). Conclusion: demonstrates that possesses antitumor potential, making it promising candidate treatment hepatic cancer. findings suggest inhibits cancer growth induces programmed death, warranting further investigation applications.

Language: Английский

Citations

0
Evaluation of Antibacterial, Antioxidant, and Anticataleptic Activity on Methanol Seed Extract of <i>Cannabis sativa</i>: An <i>In Vitro</i> and <i>In Vivo</i> Study DOI Open Access

Dasaprakash Annadurai,

Kavita Raj,

M. Francis

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2713 - 2725

Published: Dec. 31, 2024

Background: Cannabis sativa (CS) has been traditionally used for its medicinal properties, including antioxidant, antibacterial, and neuroprotective effects. However, potential anticataleptic activity remains unexplored. Aim: This study aimed to investigate the qualitative phytochemical analysis, of methanolic seed extract (CSCME). Methods: The antioxidant CSCME was evaluated using DPPH radical scavenging assay. Antibacterial properties were assessed agar well diffusion method. For study, Wistar albino rats (n=30) divided into five groups: control, disease control (haloperidol 1mg/kg), standard treatment 1mg/kg + trihexyphenidyl two groups receiving haloperidol with (10mg/kg 20mg/kg). Treatments administered daily 15 days, catalepsy severity block metal bar methods. Results: exhibited significant antibacterial comparable commercial drugs. In vivo, results showed a reduction in cataleptic scores (P<0.05) compared control. Notably, 20mg/kg group demonstrated similar reductions as (P>0.05). Conclusion: demonstrates that possesses activities, suggesting therapeutic agent managing other neurological disorders. findings warrant further investigation clinical applications CSCME.

Language: Английский

Citations

0