PLPTP: A Motif-Based Interpretable Deep Learning Framework Based on Protein Language Models for Peptide Toxicity Prediction DOI
Shun Gao,

Yulian Jia,

Feifei Cui

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169115 - 169115

Published: March 1, 2025

Language: Английский

Synthetic peptides quality control and assurance DOI

Litta Samari Perico-Franco,

Jaiver Eduardo Rosas-Pérez

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 405 - 416

Published: Jan. 1, 2025

Language: Английский

Citations

0
Optimizing the discovery bioanalysis strategy for macrocyclic peptides DOI
Xing Zhang,

Stephanie Dale,

Yusi Cui

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

Citations

0
Tyrosine Peptides Alleviates Multifaceted Toxicity Linked to Expanded CGG Repeats in Fragile X-Associated Tremor/Ataxia Syndrome DOI Creative Commons
K. P. Singh, Sakshi Shukla, Tapas Ghosh

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

0
Biotechnological Advances in GLP-1 Receptor Agonists: Development, Optimization, and Market Dynamics DOI Creative Commons
Yanze Wang

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 129, P. 122 - 129

Published: March 3, 2025

Glucagon like peptide-1 (GLP-1) receptor agonists are consequential when managing obesity and type 2 diabetes mellitus (T2DM). They regulate blood glucose level body weight by simulating the function of natural GLP-1. Through interaction with GLP-1 receptors, activate adenylate cyclase further trigger downstream cascades such as protein kinase A RAPEGEF4. This could ultimately inhibit release glucagon, at same time proliferating insulin, which would then lead to decelerated emptying gastric system accelerated sense satiety. In recent years, advances in biopharmaceutical engineering, engineering peptide synthesis, have improved pharmacokinetic properties agonists, including prolonging half-life, enhancing stability, reducing dosing frequency, thereby improving patient compliance. addition, innovation biotechnology has driven development biosimilar drugs. The current mainstream delivery methods include subcutaneous injection oral medication, while new systems nanoparticles microneedle patches optimize stability bioavailability article reviews latest progress, optimization methods, production processes, market trends future aiming provide insights into management, explore their potential applications personalized medicine combination therapy.

Language: Английский

Citations

0
PLPTP: A Motif-Based Interpretable Deep Learning Framework Based on Protein Language Models for Peptide Toxicity Prediction DOI
Shun Gao,

Yulian Jia,

Feifei Cui

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169115 - 169115

Published: March 1, 2025

Language: Английский

Citations

0