Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats DOI Creative Commons
Zhaoqing Xi, Ling Shu,

Lingling Xiao

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 596, P. 112417 - 112417

Published: Nov. 16, 2024

Obesity-associated cardiac remodeling is characterized by sympathetic nerve over-activation and pro-inflammatory macrophage infiltration. We identified norepinephrine (NE), a neurotransmitter, as effector to activate NLRP3 inflammasome, which contributed inflammation. In vivo, Sprague-Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks establish obese rat models. Obese exhibited marked hypertrophy compared normal rats. The expression of interleukin (IL)-1β was upregulated, accompanied CD68+NLRP3+ infiltration in the hearts also showed increased activity. β-adrenergic receptor (AR) inhibition mitigated these changes. vitro, neurotransmitter NE significantly exacerbated palmitic acid (PA)-induced polarization toward type inflammasome activation THP-1 macrophages. It further found that role dependent on protein kinase A (PKA) subsequently β-arrestin2, an important regulator nuclear factor-kappa B (NF-κB) pathway. This study identifies neuro-immune axis mediator obesity-associated remodeling. Targeting system may open therapeutic opportunities treatment obesity.

Language: Английский

Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling DOI Creative Commons
Min Chen, Yang Li,

Jieying Zhu

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115251 - 115251

Published: Jan. 31, 2025

Language: Английский

Citations

2
Role of deubiquitinase USP47 in cardiac function alleviation and anti-inflammatory immunity after myocardial infarction by regulating NLRP3 inflammasome-mediated pyroptotic signal pathways DOI

Zheng Wu,

Wenzheng Li,

Shaoping Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112346 - 112346

Published: June 7, 2024

Language: Английский

Citations

4
BAM15 Inhibits Endothelial Pyroptosis via the NLRP3/ASC/caspase-1 Pathway to Alleviate Atherosclerosis DOI

Su Zhong,

Hui Shen, Xiaoman Dai

et al.

Atherosclerosis, Journal Year: 2025, Volume and Issue: 406, P. 119226 - 119226

Published: May 1, 2025

Language: Английский

Citations

0
Aerobic Exercise and PI3K Inhibitor Ameliorate Obesity Cardiomyopathy by Alleviating Pyroptosis in Middle-Aged Mice DOI Open Access
Bin Yang, Jiahao Xu,

Xiaofang Dao

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4935 - 4935

Published: May 21, 2025

Obesity cardiomyopathy (OCM) represents a rapidly growing health concern globally, characterized by metabolic, structural, and functional abnormalities of the heart. Current research has demonstrated that inflammation plays pivotal role in obesity-induced cardiomyopathy, regular exercise can ameliorate lipid disturbances inflammatory effectively. However, underlying mechanisms are not fully elucidated. We investigated effects an 8-week aerobic intervention on myocardial structure, function, HFD-induced obese mice. The results revealed alleviated myocardium pyroptosis down-regulating PI3K/AKT signaling pathway. Furthermore, inhibition PI3K pathway LY294002, coupled with exercise, attenuated suppressed impairments, inflammation, pyroptosis, synergistic effect. Based these findings, we concluded eight weeks synergizes through to improve obesity-associated remodeling dysfunction. Therefore, long-term potential strategy treatment OCM.

Language: Английский

Citations

0
Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats DOI Creative Commons
Zhaoqing Xi, Ling Shu,

Lingling Xiao

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 596, P. 112417 - 112417

Published: Nov. 16, 2024

Obesity-associated cardiac remodeling is characterized by sympathetic nerve over-activation and pro-inflammatory macrophage infiltration. We identified norepinephrine (NE), a neurotransmitter, as effector to activate NLRP3 inflammasome, which contributed inflammation. In vivo, Sprague-Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks establish obese rat models. Obese exhibited marked hypertrophy compared normal rats. The expression of interleukin (IL)-1β was upregulated, accompanied CD68+NLRP3+ infiltration in the hearts also showed increased activity. β-adrenergic receptor (AR) inhibition mitigated these changes. vitro, neurotransmitter NE significantly exacerbated palmitic acid (PA)-induced polarization toward type inflammasome activation THP-1 macrophages. It further found that role dependent on protein kinase A (PKA) subsequently β-arrestin2, an important regulator nuclear factor-kappa B (NF-κB) pathway. This study identifies neuro-immune axis mediator obesity-associated remodeling. Targeting system may open therapeutic opportunities treatment obesity.

Language: Английский

Citations

0