Bee venom reduces early inflammation and oxidative stress associated with lipopolysaccharide-induced alpha-synuclein in the substantia nigra-striatum axis DOI Creative Commons
Alma Karen Lomeli-Lepe, José Luis Castañeda‐Cabral, Mónica E. Ureña‐Guerrero

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract Neuroinflammation and oxidative stress are important features in the pathogenesis development of synucleinopathies, glial activation upregulation pro-inflammatory mediators induce alpha-synuclein (α-syn) accumulation. Recent studies have shown that bee venom (BV) has beneficial effects on symptoms these neurodegenerative diseases. BV is known to exert anti-inflammatory anti-oxidative effects. Here, we investigated over different inflammatory markers, expression α-syn tyrosine hydroxylase (TH) a lipopolysaccharide (LPS)-induced rat model synucleinopathies. We examined whether (1.5 mg/kg by acupoint injection ST36 six times every 48 hours) could change TH measured western blotting, also, observed microglia astrocytes immunofluorescence, quantify proinflammatory cytokines levels (TNF-α IL-1β) ELISA, estimated lipid peroxidation activity superoxide dismutase (SOD) catalase (CAT) colorimetric kits LPS-treated rats (2.5 µg single dose intranigral injection) substantia nigra (SN) striatum (STR) brain areas. In LPS-injected brain, treatment reduced increased levels. addition, lower astrocyte SN STR. Furthermore, decreases IL-1β increases CAT These results indicate can restore possibly inhibition LPS-induced neuroinflammation oxidation, suggest be promising option for

Language: Английский

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

12
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

et al.

Published: July 12, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

Citations

10
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Marius Turnea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

Citations

8
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson’s Disease DOI

Jinyu Xu,

Hongbing Lei,

Chunhui Yang

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 8, 2025

Language: Английский

Citations

0
Metabolic Dysfunction in Parkinson’s Disease: Unraveling the Glucose–Lipid Connection DOI Creative Commons
Jeswinder Sian‐Hülsmann, Peter Riederer, Tanja Maria Michel

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2841 - 2841

Published: Dec. 13, 2024

Despite many years of research into the complex neurobiology Parkinson’s disease, precise aetiology cannot be pinpointed down to one causative agent but rather a multitude mechanisms. Current treatment options can alleviate symptomsbut only slightly slow progression and not cure disease its underlying causes. Factors that play role in causing debilitating neurodegenerative psycho-motoric symptoms include genetic alterations, oxidative stress, neuroinflammation, general inflammation, neurotoxins, iron toxicity, environmental influences, mitochondrial dysfunction. Recent findings suggest characteristic abnormal protein aggregation alpha-synuclein destruction substantia nigra neurons might due dysfunction related disturbances lipid glucose metabolism along with insulin resistance. The latter mechanism action mediated by receptor substrate docking proteins are involved neuronal survival signaling cell destruction. increased risk developing Type 2 Diabetes Mellitus endorses connection between metabolic neurodegeneration. Here, we explore highlight potential glycolipid cellular insults pathophysiology disorder, opening up new promising avenues for PD. Thus, antidiabetic drugs may employed as neuromodulators hinder disorder.

Language: Английский

Citations

3
Bee Venom Reduces Early Inflammation and Oxidative Stress Associated with Lipopolysaccharide-induced Alpha-synuclein in the Substantia Nigra-striatum Axis DOI
Alma Karen Lomeli-Lepe, José Luis Castañeda‐Cabral, Mónica E. Ureña‐Guerrero

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Language: Английский

Citations

1
Bee venom reduces early inflammation and oxidative stress associated with lipopolysaccharide-induced alpha-synuclein in the substantia nigra-striatum axis DOI Creative Commons
Alma Karen Lomeli-Lepe, José Luis Castañeda‐Cabral, Mónica E. Ureña‐Guerrero

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Abstract Neuroinflammation and oxidative stress are important features in the pathogenesis development of synucleinopathies, glial activation upregulation pro-inflammatory mediators induce alpha-synuclein (α-syn) accumulation. Recent studies have shown that bee venom (BV) has beneficial effects on symptoms these neurodegenerative diseases. BV is known to exert anti-inflammatory anti-oxidative effects. Here, we investigated over different inflammatory markers, expression α-syn tyrosine hydroxylase (TH) a lipopolysaccharide (LPS)-induced rat model synucleinopathies. We examined whether (1.5 mg/kg by acupoint injection ST36 six times every 48 hours) could change TH measured western blotting, also, observed microglia astrocytes immunofluorescence, quantify proinflammatory cytokines levels (TNF-α IL-1β) ELISA, estimated lipid peroxidation activity superoxide dismutase (SOD) catalase (CAT) colorimetric kits LPS-treated rats (2.5 µg single dose intranigral injection) substantia nigra (SN) striatum (STR) brain areas. In LPS-injected brain, treatment reduced increased levels. addition, lower astrocyte SN STR. Furthermore, decreases IL-1β increases CAT These results indicate can restore possibly inhibition LPS-induced neuroinflammation oxidation, suggest be promising option for

Language: Английский

Citations

0