Characterization of gene expression profiles in Alzheimer’s disease and osteoarthritis: A bioinformatics study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0316708 - e0316708

Published: Feb. 7, 2025

Alzheimer's disease (AD) and Osteoarthritis (OA) have been shown to a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores potential common molecular mechanisms between AD OA through bioinformatics analysis, providing new insights for clinical treatment strategies. The OA-related datasets were downloaded from gene expression database GEO. analyzed obtain differentially expressed (DEG) AD, respectively. intersection these DEGs was identify (Co-DEGs). Subsequently, Co-DEGs enriched, protein-protein interaction network constructed core genes. genes validated separate dataset, their diagnostic value analyzed. In addition, using set enrichment analysis single-gene genome variation analysis. Analysis on chips patients revealed significant changes patterns. Notably, EFEMP2 TSPO, associated with inflammatory responses, showed lower levels patients, suggesting downregulation pathological backgrounds diseases. Additionally, GABARAPL1, which is crucial maturation autophagosomes, found be upregulated conditions. These findings suggest as biomarkers therapeutic targets. However, confirm effectiveness targets, more in-depth mechanistic studies needed future, particularly explore feasibility specific combating progression by regulating suggests that shares mechanisms. identification EFEMP2, TSPO key target highlights factors Further investigation into could lead candidate targets directions OA, offering promising avenues developing effective targeted interventions.

Language: Английский

Physical activity in Alzheimer’s disease prevention: Sex differences and the roles of BDNF and irisin

Frontiers in Neuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 101189 - 101189

Published: April 1, 2025

Alzheimer's disease (AD) disproportionately affects women, with postmenopausal hormonal changes contributing to elevated risk. Physical exercise is a promising, non-pharmacological strategy mitigate cognitive decline and AD progression. Brain-derived neurotrophic factor (BDNF) irisin are key molecular mediators of exercise-induced brain health protection against pathology by promoting synaptic plasticity, neurogenesis, reducing amyloidosis, tau pathology, neuroinflammation in sex-specific mechanisms. This review explores sex gender influences on outcomes their interaction FNDC5/irisin BDNF signaling pathways the context prevention. We highlight emerging evidence interplay between exercise, sex, neuroprotective pathways, emphasizing need for sex-sensitive research designs advance precision approaches

Language: Английский

Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 24, 2024

Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by cognitive impairment and memory deficit. Even with extensive research studies, presently, there no effective treatment for the management of AD. Besides, most drugs used in AD did not avert neuropathology, still progressive status. For example, acetyl cholinesterase inhibitors are associated many adverse effects, such as insomnia nightmares. As well, acetylcholinesterase augment cholinergic neurotransmission leading to development effects related high acetylcholine level, salivation, rhinorrhea, vomiting, loss appetite, seizure. Furthermore, tacrine has poor bioavailability causes hepatotoxicity. These commonly do manage original those reasons, natural products were repurposed diseases. It been shown that phytochemicals produce neuroprotective against progression diseases different mechanisms, including antioxidant anti-inflammatory effects. Quercetin (QCN) reported exert an effect other lessening oxidative stress. In this review, electronic databases PubMed, Scopus, Web Science searched possible relevant studies article linking QCN on Findings from review highlighted mechanistic signaling pathways regarding Nevertheless, precise molecular mechanism was completely clarified. Consequently, aims discuss

Language: Английский