Probiotics Exert Gut Immunomodulatory Effects by Regulating the Expression of Host miRNAs

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

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Bifidobacterium animalis subsp. lactis TG11 ameliorates loperamide-induced constipation in mice by modulating gut microbiota

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Introduction Constipation is a common gastrointestinal disorder that can affect quality of life. Probiotics have garnered substantial attention for their potential to alleviate constipation. This study investigates the preventive effects Bifidobacterium animalis subsp. lactis TG11 on loperamide-induced constipation in mice. Methods Mice were randomly assigned normal control (NC), model (CM), and low, medium, high-dose treatment groups (LG, MG, HG). From days 1–14, LG, HG received 10 6 , 7 8 CFU/mouse TG11, respectively, while NC CM saline. On day 14, all except administered loperamide (4 mg/kg) orally induce Fecal samples collected short-chain fatty acid gut microbiota analyses. Following 16-hour fasting period, various parameters assessed 15, including intestinal motility, fecal water content, defecation status, peptide levels blood, mRNA expression SCF c-kit colonic tissue. Results significantly enhanced motility maintained content. It normalized blood MTL, SP, SS, ET-1, Gas, VIP constipated mice, promoted production, improved microbial metabolism. markedly upregulated Metagenomic sequencing revealed modulated composition, increasing abundance beneficial bacteria, particularly Muribaculum _sp. uncultured_Duncaniella . Discussion demonstrates efficacy ameliorating constipation, potentially through modulation composition.

Language: Английский

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Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer's Disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102515 - 102515

Published: Sept. 1, 2024

Language: Английский

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Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1386 - 1386

Published: Nov. 14, 2024

Background: The gut microbiota constitutes a complex microorganism community that harbors bacteria, viruses, fungi, protozoa, and archaea. human bacterial has been extensively proven to participate in metabolism, immunity, nutrient absorption. Its imbalance, namely “dysbiosis”, linked disordered metabolism. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the features deranged metabolism leading cause cirrhosis hepatocellular carcinoma. Thus, there pathophysiological link between dysbiosis MASLD. Aims Methods: We aimed review literature data on composition its MASLD describe concept “gut–liver axis”. Moreover, we reviewed approaches for modulation treatment. Results: There consolidated evidence particular associated with stages. model explaining relationship bidirectional organization, physiopathology Oxidative stress keystones pathophysiology fibrosis generation. promising efficacy pre- probiotics reversing patients, therapeutic effects. Few yet encouraging fecal transplantation (FMT) are available literature. Conclusions: characteristic key target reversal treatment via diet, pre/probiotics, FMT remains treatment, prevention, reversal.

Language: Английский

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Bridging dietary polysaccharides and gut microbiome: how to achieve precision modulation for gut health promotion

Microbiological Research, Journal Year: 2025, Volume and Issue: 292, P. 128046 - 128046

Published: Jan. 2, 2025

Language: Английский

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Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 28, 2025

Introduction The global health challenge of ulcerative colitis (UC) has been classified by the WHO as a modern refractory disease, commonly referred to green cancer, with limited treatment options still available, highlighting urgent need for development new therapeutic strategies. Recent pharmacological research shown that traditional Chinese medicine saussurea costus (SC) possesses beneficial antibacterial and anti-inflammatory properties. Nevertheless, its underlying mechanism remains elusive. Methods Firstly, we identified main active components SC through UHPLC-QTOF-MS analysis. Subsequently, UC mice were induced using DSS administered different doses evaluate efficacy. Additionally, impact on repair intestinal mucosal barrier was evaluated immunofluorescence western blot. Furthermore, 16s rRNA gene sequencing conducted elucidate contribution gut microbiota pathogenesis. Results primary include Proline, Phenylalanine, Isoleucine, Lucidenic acid M, Pyroglutamic acid. efficacy concurrently assessed, revealing potential ameliorate histological injury in mice. found decrease levels TNF-α, IL-1β, IL-8, IL-18 while promoting expression IL-10 IL-22. Similarly, also ZO-1 Occludin reversed In addition, analysis 16S indicated reduced harmful bacterial populations, such Proteobacteria , simultaneously enhancing bacteria like Lactobacillus thereby contributing improvement pathology. Conclusion This study highlights managing ability attenuate inflammatory responses, restore functionality, modulate composition, which findings offer insights into strategies advancing treatment.

Language: Английский

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Effect of Supplementation of Quercetagetin on the Antioxidant Function, Liver Mitochondrial Function and Gut Microbiota of Broilers at High Stocking Density

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 398 - 398

Published: Jan. 31, 2025

This study investigates the effects of quercetagetin (QG) supplementation on antioxidant capacity, liver mitochondrial function, and cecal microbiota broilers raised under high-density conditions. A 2 × factorial design with 144 one-day-old WOD168 broilers, which were allocated to two stocking densities (LD: 4 birds per cage, equivalent 11.1 square meter; HD: eight 22.2 meter) levels dietary QG (0 20 mg/kg). At conclusion day 21, similar body weights randomly into four groups (22 42 d): control (CON), treatment (QG), high density (HSD), (H_QG). The results demonstrated that HD significantly reduced broiler growth performance, including weight (BW), average daily gain (ADG), feed intake (ADFI) (p < 0.05). Additionally, increased serum stress hormone (CORT ACTH), pro-inflammatory cytokines (IL-1β IL-6) 0.05), while decreasing enzyme activities (GSH-Px, T-SOD), CAT T-SOD activities, function (GSH, complex I-III, ATP contents) However, mg/kg alleviated negative induced by HSD, restoring levels, immune parameters, function. Moreover, markedly improved composition, enhancing gut health. Correlation analysis revealed a strong association between microbial composition overall health, indicating plays critical role in mediating these beneficial effects. In conclusion, exhibits protective against oxidative stress, dysfunction, imbalance rearing, suggesting its potential as functional additive improve health intensive farming

Language: Английский

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Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

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Body mass index changes after fecal microbiota transplantation for recurrent Clostridioides difficile infection

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Background: Fecal microbiota transplantation (FMT) is a successful therapy for Clostridioides difficile infection (CDI). FMT from overweight donors speculated to influence the recipient’s body mass index (BMI) after administration CDI. Objectives: We investigated changes in BMI relation donor’s BMI. Design: conducted retrospective cohort study involving patients who underwent recurrent CDI at Mayo Clinic between 2012 and 2019. Methods: analyzed demographic donor data undergoing (2012–2019). Recipient (pre- post-FMT) were extracted medical records. Mixed-effects linear regression was used evaluate impact of BMI, category, recipient baseline time before FMT, interactions these variables on overall change per month. Kaplan–Meier curves assess (⩾5 units) based last recorded post-FMT Results: 401 with measurements FMT. The median age recipients 59.1 years (interquartile range (IQR): 40.5–70.1 years), 61.6% being female. prior 26.7 kg/m² (IQR: 22.7–31.6 kg/m²), while 24.5 kg/m 2 23.9–27.5 ). Stool normal 58.2% recipients, 41.8% received stool pre-obese donors. Donor missing 3.2% recipients. not significantly associated BMI; each 1-unit increase 0.01-unit monthly observed (95% confidence interval: −0.0003, 0.02; p = 0.11). log-rank test increases (⩾+5) decreases (⩽−5) revealed no significant differences among groups (Chi-squared 4.4, 0.1 increases, Chi-squared 2, 0.4 decreases). Conclusion: lack suggests that are more dependent metabolic profile. Prospective, controlled trials required analyze results comprehensively.

Language: Английский

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Intestinal Management and Assessment Based on Convolutional Neural Network

Modeling and Simulation, Journal Year: 2025, Volume and Issue: 14(02), P. 758 - 767

Published: Jan. 1, 2025

Language: Английский

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