Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(4), P. 785 - 803

Published: Feb. 5, 2024

Language: Английский

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Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission

IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: 16, P. 86 - 97

Published: Jan. 3, 2024

A decrease in the levels of antioxidant arsenals exacerbate generation reactive oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on pathogenesis psychotic disorders such as schizophrenia. This study examined preventive and reversal effects diosgenin, a phyto-steroidal saponin functions mice treated ketamine which closely replicates schizophrenia-like symptoms human laboratory animals. In phase, adult cohorts were clustered into 5 groups (n = 9). Groups 1 2 received saline (10 mL/kg, i.p.), 3 4 pretreated diosgenin (25 50 mg/kg), group risperidone (0.5 mg/kg) orally for 14 days. Mice 2-5 additionally daily dose (20 mg/kg, i.p.) or mL/kg/day, i.p.). intraperitoneal injection consecutive days prior mg/kg/p.o./day) treatment from 8-14. assessed behavioral changes. Oxidative, nitrergic markers, cholinergic (acetylcholinesterase activity) transmission striatum, prefrontal-cortex hippocampus. Diosgenin prevented reversed hyperlocomotion, cognitive social deficits relative groups. The increased acetylcholinesterase, malondialdehyde nitrite produced by reduced hippocampus, but did not reverse striatal level. glutathione, catalase levels, except hippocampal activity when compared controls. Conclusively, these biochemical changes might be related ketamine-treated mice, diosgenin.

Language: Английский

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Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: Attenuation by geraniol

Neurochemistry International, Journal Year: 2024, Volume and Issue: 177, P. 105748 - 105748

Published: May 3, 2024

Language: Английский

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The protective role of ginsenoside Rg3 in heart diseases and mental disorders

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Ginsenoside Rg3, a compound derived from

Language: Английский

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Ketamine-Induced Behavioral Perturbations, Redox Imbalances, and Neurotransmitter Deficits in Mice: The Preventive and Reversal Neuromodulatory Potential of Diosmin as an Antipsychotic

Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100210 - 100210

Published: March 1, 2025

Language: Английский

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Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic stress disorder

Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 168, P. 165 - 175

Published: Oct. 27, 2023

Language: Английский

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Diosgenin reverses posttraumatic stress disorder in mice by augmenting neurochemical release and inhibiting HPA axis dysfunction, oxidative stress, and neuroinflammation

Journal of Affective Disorders Reports, Journal Year: 2024, Volume and Issue: 17, P. 100814 - 100814

Published: June 26, 2024

Post-traumatic stress disorder (PTSD) is a mental linked to neurochemical, hypothalamic-pituitary-adrenal (HPA)-axis dysregulations, inflammatory and pro-oxidant challenges in response traumatic events. It one of the leading causes neurocognitive declines, hence prompting need for pharmacological intervention. However, impact diosgenin, naturally occurring steroidal saponin with adaptogenic-like action, on PTSD-induced neuropsychiatric disturbances its underlying mechanisms are unknown. In this study, we investigated outcome diosgenin treatment multimodal traumatic, single prolonged (SPS)-induced PTSD mice. Following SPS-induced 7 days PTSD, mice (n = 9) were thereafter treated (25 50 mg/kg) or fluoxetine (10 orally from 8–20 (14 days). Locomotory, cognitive-, depressive- anxiety-like behaviors investigated. We assayed changes adrenal weight, serum glucose corticosterone concentrations. Neurochemical, inflammatory, oxido-nitrergic dysfunctions monoamine oxidase-B acetylcholinesterase activities, measured striatum, prefrontal-cortex hippocampus. The results revealed that SPS challenge inhibited locomotor, spatial/non-spatial memory functions, increased anxiety depressive-like features, which reversed by diosgenin. Diosgenin reduced oxidase-B, TNF-α, IL-6, malondialdehyde nitrite levels Antioxidants such as glutathione, superoxide-dismutase, catalase SPS-mice brains Moreover, attenuated hyper-HPA-axis mediation decreasing corticosterone, gland hypertrophy. Herewith, suggest convenes protection against exposed enhancing antioxidant machinery, neurochemical modulations, inhibition oxido-nitrergic, HPA-axis dysfunctions.

Language: Английский

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Effective Action of Silymarin against Ketamine-induced Schizophrenia in Male Mice: Insight into the Biochemical and Molecular Mechanisms of Action

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 179, P. 141 - 155

Published: Sept. 13, 2024

Language: Английский

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Reversal and Preventive Pleiotropic Mechanisms Involved in the Antipsychotic-Like Effect of Taurine, an Essential β-Amino Acid in Ketamine-Induced Experimental Schizophrenia in Mice

Neurochemical Research, Journal Year: 2022, Volume and Issue: 48(3), P. 816 - 829

Published: Nov. 9, 2022

Language: Английский

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Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 15, 2023

Brain aging, which involves a progressive loss of neuronal functions, has been reported to be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and accelerated aging are linked changes epigenetic clocks. Recent cross-sectional magnetic resonance imaging analyses have uncovered reduced brain reserves connectivity patients with compared typically individuals. These data may indicate early abnormalities function following cyto-architectural alterations SCZ. The current mechanistic knowledge on changes, their neuropsychiatric disease association remains incomplete. With this review, we explore summarize evidence the dynamics gut-resident bacteria can modulate molecular contribute age-related neurodegenerative disorders. It is known environmental factors such as mode birth, dietary habits, stress, pollution, infections microbiota system regulate intrinsic activity through vagus nerve enteric nervous system. Microbiota-derived molecules trigger continuous activation microglial sensome, groups receptors proteins permit microglia remodel neurochemistry based complex activities. This remodeling causes aberrant plasticity fetal developmental stages, after onset first-episode psychosis. In central system, microglia, resident immune surveillance cells, involved neurogenesis, phagocytosis synapses neurological dysfunction. Here, review recent emerging experimental clinical regarding gut-brain axis involvement pathology etiology, hypothesis reserve induced infections, other factors. We also include our possibilities consequences gut dysbiosis activities dysfunction, together effects antipsychotics microbiome: therapeutic adverse effects, role fecal transplant psychobiotics sensomes, SCZ-derived aging. end suggestions applicable setting. For example, propose might antipsychotic-induced benefits or well reduce process axis. Overall, hope will help increase understanding pathogenesis related chronobiology microbiome, reveal new concepts serve novel treatment targets for

Language: Английский

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