Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats DOI Creative Commons
Karol Rycerz, Aleksandra Krawczyk, Jadwiga Jaworska-Adamu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2763 - 2763

Published: Dec. 4, 2024

Background Monosodium glutamate (MSG) in its anionic form, glutamate, is one of the main excitatory amino acids. Excess this neurotransmitter may lead to excitotoxicity affecting neurons and astrocytes responsible for metabolism different brain areas animals. The aim study was investigate immunoreactivity glial fibrillary acidic protein (GFAP) S100β caudate nucleus rats under condition elevated levels. Methods: Fifteen were divided into a control group receiving saline MSG2 MSG4 groups 2 g/kg b.w. MSG 4 MSG, respectively, 3 days. An immunohistochemical reaction conducted on frontal sections containing with use antibodies against GFAP S100β. Results: Analyses indicated density immunoreactive studied proteins animals MSG. cells also demonstrated increased immunostaining intensity both especially group. number GFAP-positive processes similar all groups. Conclusions: studies demonstrate potential response effect administration nucleus. It shown that GFAP- S100β-positive act differently, suggesting distinct roles these excitotoxicity.

Language: Английский

The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats DOI Creative Commons
Amina E. Essawy,

Eman M. Jimmiey,

Wessam M. Abdel-Wahab

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 29, 2025

Language: Английский

Citations

0
The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice DOI Creative Commons
Susan L. Prescott, Kathleen F. Holton, Christopher A. Lowry

et al.

NeuroSci, Journal Year: 2024, Volume and Issue: 5(3), P. 354 - 377

Published: Sept. 23, 2024

Over the last decade there has been increasing interest in links between consumption of ultra-processed foods and various neuropsychiatric disorders, aggression, antisocial behavior. Neurolaw is an interdisciplinary field that seeks to translate rapid voluminous advances brain science into legal decisions policy. An enhanced understanding biophysiological mechanisms by which influence behavior allows for a historical reexamination one forensic neuropsychiatry's most famous cases-

Language: Английский

Citations

2
Albino Wistar Rats: Advantages and Limitations in Biomedical Research DOI Open Access

P. Krubaa,

P. S. Yogitha

SBV Journal of Basic Clinical and Applied Health Science, Journal Year: 2024, Volume and Issue: 7(2), P. 61 - 65

Published: April 1, 2024

Abstract Albino Wistar rats refer to a strain of the which is part Norway rat species; it popular animal model in many areas research specifically neuroscience, pharmacology, and toxicology among others. These are particularly valuable due their high level genetic homogeneity, ease handling, reproducible results have kept them list requirements for researchers who want minimize extraneous variables studies. One can bet on fact that inbred, therefore, even disposition normalized. originated from United States America 19 th century. In several generations breeding, this was used establish desired characteristics, resulted greatly reduced variability. Thus, throughout whole process research, one be sure study will not any relation differences participants. addition, kind inoffensive takes well experimental environment. This ensures animals do subdued or fought before getting sample does stress researcher. Furthermore, they shorter gestation period, approximately 21 days, short existence 2 years. Such features make suitable by would wish get fast result those small budget. It should also pointed out, although, there some drawbacks employing as subjects well. The following major drawback; prone certain diseases example infections types tumors. means studied population may higher sensitivity disease its manifestations, influence studies, when processes potential treatments examined. other limitation has relatively life span than rats. Reduced expectancy reduce possibilities especially trials concerned with aging late outcomes interventions. Experimentalists must put these aspects into consideration choosing type use. Nevertheless, despite drawbacks, still considered source taking account all mentioned advantages. Because reproducibility, uniformity, ability adapt laboratory conditions, provide perfect dissecting complex biological functions generating new models affecting mankind. Due advancement scientific knowledge technology, 1 day overcome said-named limitations associated use models.

Language: Английский

Citations

1
Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats DOI Creative Commons
Karol Rycerz, Aleksandra Krawczyk, Jadwiga Jaworska-Adamu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2763 - 2763

Published: Dec. 4, 2024

Background Monosodium glutamate (MSG) in its anionic form, glutamate, is one of the main excitatory amino acids. Excess this neurotransmitter may lead to excitotoxicity affecting neurons and astrocytes responsible for metabolism different brain areas animals. The aim study was investigate immunoreactivity glial fibrillary acidic protein (GFAP) S100β caudate nucleus rats under condition elevated levels. Methods: Fifteen were divided into a control group receiving saline MSG2 MSG4 groups 2 g/kg b.w. MSG 4 MSG, respectively, 3 days. An immunohistochemical reaction conducted on frontal sections containing with use antibodies against GFAP S100β. Results: Analyses indicated density immunoreactive studied proteins animals MSG. cells also demonstrated increased immunostaining intensity both especially group. number GFAP-positive processes similar all groups. Conclusions: studies demonstrate potential response effect administration nucleus. It shown that GFAP- S100β-positive act differently, suggesting distinct roles these excitotoxicity.

Language: Английский

Citations

0