Trends and research focus on autophagy in Alzheimer's disease (2003–2023): A bibliometric study DOI
Tianyi Wang, Haochen Jiang, Ruwen Zheng

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Background Alzheimer's disease (AD) is characterized by amyloid-β plaques and tau aggregates, with autophagy dysfunction playing a key pathogenic role. While modulation shows therapeutic promise, comprehensive bibliometric analyses are lacking. Objective This study aims to map the research landscape of in AD through analysis, identifying trends, contributors, emerging focus areas. Methods We analyzed 4018 publications (2003–2023) from Web Science using VOSviewer CiteSpace. Publication influential authors, countries, institutions, hotspots were examined co-occurrence, burst detection, clustering analyses. Results Annual have steadily increased, peaking 2022. The US led output citations, major contributions University California New York University. Ralph A. Nixon emerged as most author. Early (2003–2013) primarily focused on protein degradation mechanisms, whereas recent studies (2014–2023) emphasize mitochondrial dysfunction, apoptosis, related pathways. Key evolving topics include endoplasmic reticulum stress chaperone-mediated autophagy, significant implications for innovation. Conclusions Autophagy plays critical role pathogenesis represents promising target. Despite mechanistic advances, clinical translation remains challenging. Future should prioritize multi-omics integration, drug delivery optimization, managing risks associated excessive activation. These findings provide valuable insights developing novel therapies targeting autophagy.

Language: Английский

Trends and research focus on autophagy in Alzheimer's disease (2003–2023): A bibliometric study DOI
Tianyi Wang, Haochen Jiang, Ruwen Zheng

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Background Alzheimer's disease (AD) is characterized by amyloid-β plaques and tau aggregates, with autophagy dysfunction playing a key pathogenic role. While modulation shows therapeutic promise, comprehensive bibliometric analyses are lacking. Objective This study aims to map the research landscape of in AD through analysis, identifying trends, contributors, emerging focus areas. Methods We analyzed 4018 publications (2003–2023) from Web Science using VOSviewer CiteSpace. Publication influential authors, countries, institutions, hotspots were examined co-occurrence, burst detection, clustering analyses. Results Annual have steadily increased, peaking 2022. The US led output citations, major contributions University California New York University. Ralph A. Nixon emerged as most author. Early (2003–2013) primarily focused on protein degradation mechanisms, whereas recent studies (2014–2023) emphasize mitochondrial dysfunction, apoptosis, related pathways. Key evolving topics include endoplasmic reticulum stress chaperone-mediated autophagy, significant implications for innovation. Conclusions Autophagy plays critical role pathogenesis represents promising target. Despite mechanistic advances, clinical translation remains challenging. Future should prioritize multi-omics integration, drug delivery optimization, managing risks associated excessive activation. These findings provide valuable insights developing novel therapies targeting autophagy.

Language: Английский

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