Late-Stage Functionalization of the 4-amino-2-Pyridone Chemotype Using Electrochemical and MCR approaches DOI
Lisa Giannessi,

Matteo Longo,

Chiara Massera

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(81), P. 11500 - 11503

Published: Jan. 1, 2024

We report the development and application of different strategies for late-stage functionalization (LSF) biologically relevant 4-amino-2-pyridone chemotype. Using recently discovered PCSK9 inhibitor 5c as a prototype, series electrochemical LSF (e-LSF) multicomponent (MCR-LSF) have been set-up to decorate scaffold. The usefulness these methods has demonstrated by generating novel derivatives in site-selective sustainable way.

Language: Английский

One-pot multi-component synthesis of novel chromeno[4,3-b]pyrrol-3-yl derivatives as alpha-glucosidase inhibitors DOI Open Access

Malihe Karami,

Alireza Hasaninejad, Hossein Mahdavi

et al.

Molecular Diversity, Journal Year: 2021, Volume and Issue: 26(5), P. 2393 - 2405

Published: Oct. 25, 2021

Language: Английский

Citations

29
Catalyst‐free access to substituted pyrano[4,3‐b]pyrrol‐4(1H)‐one derivatives through domino reaction in water DOI
Chunmei Li,

Wenliang Wu,

Kai Yin

et al.

Journal of Heterocyclic Chemistry, Journal Year: 2023, Volume and Issue: 60(5), P. 847 - 858

Published: Feb. 15, 2023

Abstract Thus far, domino‐based reactions have received a great deal of attention as step‐and atom‐economic route toward the synthesis plethora heterocyclic molecules. In this work, we disclose catalyst‐free domino procedure for rapid 3‐substituted 6‐methyl‐1,2‐diarylpyrano[4,3‐ b ]pyrrol‐4(1 H )‐one compound in water at 80°C, accompanied by multiple C‐H/C‐O bond cleavage and C‐C C‐N formation. This approach is characterized its mild reaction conditions, convenient separation, high tolerance functional groups, easily available starting materials, thereby offering green efficacious strategy design pyrano[4,3‐ derivatives reaction.

Language: Английский

Citations

3
Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies DOI
H.L. Siddiqui, M. A. A. Baheej, Naeem Ullah

et al.

Molecular Diversity, Journal Year: 2021, Volume and Issue: 26(4), P. 2049 - 2067

Published: Oct. 4, 2021

Language: Английский

Citations

7
Late-Stage Functionalization of the 4-amino-2-Pyridone Chemotype Using Electrochemical and MCR approaches DOI
Lisa Giannessi,

Matteo Longo,

Chiara Massera

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(81), P. 11500 - 11503

Published: Jan. 1, 2024

We report the development and application of different strategies for late-stage functionalization (LSF) biologically relevant 4-amino-2-pyridone chemotype. Using recently discovered PCSK9 inhibitor 5c as a prototype, series electrochemical LSF (e-LSF) multicomponent (MCR-LSF) have been set-up to decorate scaffold. The usefulness these methods has demonstrated by generating novel derivatives in site-selective sustainable way.

Language: Английский

Citations

0