WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatment

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Targeted protein degradation (TPD) is a promising approach that has the ability to address disease-causing proteins. Compared traditional inhibition, proteolysis targeting chimera (PROTAC) technology offers various benefits, including potential target mutant and overexpressed proteins along with characteristics undruggable proteomes. A significant obstacle ongoing effective treatment of malignancies cancer drug resistance, which developed frequently by mutated or targets causes current remedies continuously lose their effectiveness. The use PROTACs degrade have undergone mutations conferred resistance first-line therapies attracted much research attention. To find novel/effective treatments, we analyzed advancements in aimed at targets. This review provides description how PROTAC-based anticancer drugs are currently being counter if PROTAC technology. Moreover, modern technologies related degradation, autophagy-targeting chimeras (AUTAC), lysosome-targeting (LYTAC), antibody-based (AbTAC), Glue-body (GlueTAC), transcription-factor-targeting (TRAFTAC), RNA-PROTAC, aptamer-PROTAC, Photo-PROTAC, folate-PROTAC, in-cell click-formed (CLIPTACs), been discussed mechanisms action.

Language: Английский

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Moving Beyond Amyloid in Alzheimer's Therapeutics

GEN Biotechnology, Journal Year: 2023, Volume and Issue: 2(2), P. 69 - 75

Published: April 1, 2023

Language: Английский

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