Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 6971 - 6988
Published: Oct. 1, 2024
Hypertension (HTN) is closely related to endothelial damage. While tianma (TM) and gouqizi (GQZ) have the potential be effective in treatment of HTN traditional Chinese medicine, their main active ingredients whether its exert synergistic effects underlying mechanisms are still unclear.
Language: Английский
Journal of Clinical Pharmacy and Therapeutics, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Backgrounds: The Zao Ren An Shen (ZRAS) Capsule, stemming from a traditional Chinese herbal formula, is recognized as safe and effective sleep‐regulating medication. Asthma often worsens during the night early morning due to its distinct day–night rhythm, suggesting potential for ZRAS Capsule intervene in asthma attacks prognosis. Since inflammation primary mechanism asthma, exploring anti‐inflammatory effects of essential. Methods: This study identifies intersection Capsule‐related targets uncover mechanisms. Core compounds relevant genes were identified using protein–protein compound–protein interaction networks. KEGG pathway Gene Ontology analyses performed on validate their role mitigating inflammation. Binding activities between assessed western blot, qRT‐PCR, molecular docking, immunohistochemistry (IHC). Results: Key compounds, including luteolin, (S)‐Coclaurine, zizyphusine, along with IL6, TNF, MMP9, identified. Their biological processes linked IL‐17 signaling TNF pathway. Notably, inhibited mRNA protein expression MMP9. Conclusion: Regulation IL‐17/TNF likely crucial protective treatment.
Language: Английский
Citations
0
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
ABSTRACT Insomnia, a prevalent sleep disorder, significantly impacts global health. While Western medications provide temporary relief, their risks of dependency and cognitive impairment have spurred the search for safer alternatives. Traditional Chinese Medicine (TCM) offers promising approach to treating insomnia by focusing on harmonizing balance Yin Yang functions internal organs. This review explores recent research advances in TCM treatment, integrating classical theories with modern scientific understanding key pathological mechanisms, including neurotransmitter regulation (GABA, monoamines), immune‐inflammatory responses, HPA axis, interactions gut microbiota. Growing clinical evidence supports effectiveness prescriptions treatments like acupuncture improving quality, particularly when combined enhance efficacy reduce dependency. However, also has its limitations. Future directions should focus modernizing applications, addressing comorbidities associated insomnia, exploring role microbiota, optimizing medicinal edible homologous products. By traditional knowledge cutting‐edge technologies, holds great potential advancing personalized effective globally.
Language: Английский
Citations
0
Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 337, P. 113595 - 113595
Published: Aug. 29, 2024
Language: Английский
Citations
1
International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(11)
Published: Oct. 30, 2024
Abstract Ethnopharmacological Relevance Sjögren's syndrome (SJS) and dry eye (DES) are characterized by ocular dryness from inadequate tear production or excessive evaporation. To evaluate the effectiveness of TBDESJS (Chun‐Yu‐Ching‐Hua‐Yin, CYCHY), a TCM tea bag, in treating SJS DES patients compared with healthy controls (NHC). Materials Methods This phase II pilot study included 100 participants (60 SJS, 30 DES, 10 NHC) across 8 weeks, assessing changes Schirmer's test, OSDI, ESSPRI, PSQI, FIRST, artificial usage, using repeated measurement ANOVA Tukey's honestly significant difference (HSD) for analysis. Results Total 97 subjects completed trial, left (OS) improvements at 4, weeks were observed (0.13 ± 0.43–5.77 2.87, 7.60 4.84 mm) (0.21 0.41–6.21 2.97, 7.86 3.47 (all p < .001). For right (OD), 0.39–6.77 4.53, 8.79 5.92 (0.34 0.55–6.59 2.50, 8.24 3.42 Secondary outcomes showed reduced ESSPRI scores (6.37 1.97–5.57 1.79, .001) (6.10 1.97–5.28 2.23, .05). PSQI global improved significantly all groups ( Artificial usage decreased (4.93 2.45–1.00 0.82 times/day), (4.47 1.99–0.66 0.67 times/day) No serious adverse events this study. Conclusion production, dryness, sleep quality, indicating potential neural regulation, anti‐inflammatory immunomodulatory benefits. These findings advocate CYCHY)'s comprehensive therapeutic value treatment, emphasizing need further research to understand long‐term effects mechanisms.
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 6971 - 6988
Published: Oct. 1, 2024
Hypertension (HTN) is closely related to endothelial damage. While tianma (TM) and gouqizi (GQZ) have the potential be effective in treatment of HTN traditional Chinese medicine, their main active ingredients whether its exert synergistic effects underlying mechanisms are still unclear.
Language: Английский
Citations
0