Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2911 - 2911

Published: March 2, 2024

This paper delves into the diverse and significant roles of curcumin, a polyphenolic compound from Curcuma longa plant, in context cancer inflammatory diseases. Distinguished by its unique molecular structure, curcumin exhibits potent biological activities including anti-inflammatory, antioxidant, potential anticancer effects. The research comprehensively investigates curcumin’s interactions with key proteins involved progression response, primarily through docking studies. In cancer, effectiveness is determined examining interaction pivotal like CDK2, CK2α, GSK3β, DYRK2, EGFR, among others. These suggest role impeding cell proliferation survival. Additionally, highlights impact on inflammation influence such as COX-2, CRP, PDE4, MD-2, which are central to pathway. vitro clinical studies extensively reviewed, shedding light binding mechanisms, pharmacological impacts, therapeutic application various cancers conditions. understanding functionality agent. Conclusively, this review emphasizes promise treating wide range health issues, attributed complex chemistry broad properties. points towards growing importance multi-faceted natural medical scientific community.

Language: Английский

Molecular and phylogenetic characterization of the monkeypox outbreak in the South of Spain

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(3)

Published: March 1, 2024

Abstract Background and Aim Until the May 2022 Monkeypox (MPXV) outbreak, which spread rapidly to many non‐endemic countries, virus was considered a viral zoonosis limited some African countries. The Andalusian circuit of genomic surveillance applied characterize MPXV outbreak in South Spain. Methods Whole genome sequencing used obtain profiles samples collected across south Spain, representative all provinces Andalusia. Phylogenetic analysis study relationship isolates available sequences outbreak. Results total 160 viruses from different that reported cases were obtained. Interestingly, we report obtained two patients who died. While one bore no noteworthy mutations explain potential heightened virulence, another patient second consecutive sequence, performed after administration tecovirimat, uncovered mutation within A0A7H0DN30 gene, known be prime target for tecovirimat its Vaccinia counterpart. In general, low number observed reported, very similar reference (OX044336), as expected DNA virus. likely correspond several introductions circulating last sequenced died presented gene bears connections drug resistance. This absent initial before treatment.

Language: Английский

Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 17, 2024

Cytotoxic adenosine analogues were among the earliest chemotherapeutic agents utilised in cancer treatment. Cordycepin, a natural derivative of discovered fungus Ophiocordyceps sinensis, directly inhibits tumours not only by impeding biosynthesis, inducing apoptosis or autophagy, regulating cell cycle, and curtailing tumour invasion metastasis but also modulates immune response within microenvironment. Furthermore, extensive research highlights cordycepin’s significant therapeutic potential alleviating hyperlipidaemia glucose metabolism. This review comprehensively analyses structure-activity relationship cordycepin its analogues, outlines pharmacokinetic properties, strategies to enhance bioavailability. Delving into molecular biology, it explores pharmacological mechanisms suppression metabolic disorder treatment, thereby underscoring immense drug development these domains laying groundwork for innovative treatment strategies.

Language: Английский