Application and progress of functionalized magnetic bead-based biosensors for protein detection DOI Creative Commons

Haoyuan Su,

Yuehua Liao,

Shu Yuen Wu

et al.

Progress in Medical Devices, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

In the field of bioanalysis, integration magnetic beads and biosensors provides a protein detection platform with high separation efficiency sensitivity. The superparamagnetism beads, combined surface functional modifications, forms basis for selectively capturing effectively separating target proteins. Additionally, sensitivity specificity ensure precise quantitative analysis captured This article systematically reviews synthesis strategies functionalized methods proteins nucleic acids, as well current technical challenges future development directions.

Language: Английский

A Compendium of Magnetic Nanoparticle Essentials: A Comprehensive Guide for Beginners and Experts DOI Creative Commons
Carlos O. Amorim

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 137 - 137

Published: Jan. 20, 2025

Magnetic nanoparticles (MNPs) are advanced materials that combine the unique properties of magnetic and nanoscale dimensions, enabling a wide range applications in biomedicine, environmental science, information technology. This review provides comprehensive yet accessible introduction to fundamental principles, characterization techniques, diverse MNPs, with focus on their properties, such as superparamagnetism, single-domain behavior, surface effects. It also delves into classification critical role parameters like anisotropy blocking temperature. Emphasis is placed routine methods, including X-ray diffraction, electron microscopy, magnetometry, well concepts hyperthermia self-regulated heating. Designed for newcomers experts alike, this serves both an educational guide quick-reference resource, ensuring clarity while maintaining scientific rigor.

Language: Английский

Citations

0
From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies DOI Creative Commons
Dongyue Xie,

Linglin Sun,

Manxiang Wu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.

Language: Английский

Citations

0
Magnetic hyperthermia mediated multimodal therapy for tumors: Construction and potential applications of iron-based nanoplatforms DOI
Yifei Wang,

Jianing Chu,

X Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216575 - 216575

Published: March 18, 2025

Language: Английский

Citations

0
Effect of graphene oxide on Fe3O4/TiO2 nanocomposite and their characterization for drug delivery applications DOI

Noshin Salimi,

Ebrahim Mohammadi‐Manesh

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114387 - 114387

Published: March 1, 2025

Language: Английский

Citations

0
Polymer-Functionalized Magnetic Nanoparticles for Targeted Quercetin Delivery: A Potential Strategy for Colon Cancer Treatment DOI Creative Commons
Júlia Borges de Macedo, Javier Bueno, Carla Cristine Kanunfre

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 467 - 467

Published: April 3, 2025

Background/Objectives: Nanoparticle-based drug delivery systems improve pharmacokinetic aspects, including controlled release and targeting, increasing therapeutic efficacy, reducing toxicity in conventional colon cancer treatment. The superparamagnetism of magnetic nanoparticles (MNP) appears to be a potential alternative for magnetothermal therapy, inducing tumor cell death by an external field. Therefore, this study aimed develop chitosan (CS) folate-chitosan (FA-CS)-coated MNP the stability targeting system quercetin (Q) delivery. Methods: After FA-CS synthesis 32 factorial design, polymer-functionalized MNPs were produced loading, characterized, evaluated dissolution cytotoxicity assay. Results: design indicated positive influence CS on MNPs’ Zeta potential, followed CS–temperature interaction. Optimized formulations had hydrodynamic diameters 122.32 ± 8.56 nm, potentials +30.78 0.8 mV, loading efficiencies 80.45% (MNP-CS-Q) 54.4% (MNP-FA-CS-Q). 24 h was MNP-CS-Q (up 6.4%) MNP-FA-CS-Q 7.7%) simulated medium, with Fickian diffusion mechanism correlated Korsmeyer–Peppas model (R > 0.99). assay HCT-116 showed higher (p < 0.001) dose-dependent antitumor effect quercetin-loaded compared free drug, IC50s 1.46 (MNP-CS) 1.30 µg·mL−1 (MNP-FA-CS). Conclusions: contributes development biomedical nanotechnology debate highlighting nanoparticles. experimental allows discussion critical manufacturing variables determination optimal parameters formulations.

Language: Английский

Citations

0
An efficient, green and solvent-free three-component synthesis of 2,4,6-triarylpyridines utilizing ZSM-5 as a heterogeneous catalyst DOI
Navnath T. Hatvate, Juhi Gupta

Synthetic Communications, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Sept. 12, 2024

Language: Английский

Citations

1
Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy DOI Creative Commons
Lenka Rajsiglová, Michal Babič,

Kateřina Krausová

et al.

Journal of Immunotoxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 1, 2024

Nanoparticles are commonly used in diagnostics and therapy. They also increasingly being implemented cancer immunotherapy because of their ability to deliver drugs modulate the immune system. However, effect nanoparticles on cells involved anti-tumor response is not well understood. The study reported here showed that nickel-doped maghemite (FN NP) differentially cytotoxic cultured mouse human cell lines, causing death without negatively impacting subsequent anticancer response. It found FN NP induced colorectal line CT26 prostate PC-3, but LNCaP. did affect phenotype responsivity isolated peritoneal macrophages, or ex vivo-generated bone marrow-derived, monocyte-derived dendritic cells. Additionally, prevent from stimulating lymphocytes enriching cultures with cell-reactive T-cells. In conclusion, this shows could be a valuable platform for targeting immunosuppressive effects

Language: Английский

Citations

0
Application and progress of functionalized magnetic bead-based biosensors for protein detection DOI Creative Commons

Haoyuan Su,

Yuehua Liao,

Shu Yuen Wu

et al.

Progress in Medical Devices, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

In the field of bioanalysis, integration magnetic beads and biosensors provides a protein detection platform with high separation efficiency sensitivity. The superparamagnetism beads, combined surface functional modifications, forms basis for selectively capturing effectively separating target proteins. Additionally, sensitivity specificity ensure precise quantitative analysis captured This article systematically reviews synthesis strategies functionalized methods proteins nucleic acids, as well current technical challenges future development directions.

Language: Английский

Citations

0