Optoelectronic characterizations, and RT-NH3 gas sensing application of newly synthesized spiro[indoline-3,4′-pyrano[2,3-b]pyridine]derivative DOI

E. Kh. Shokr,

Mahmoud Abd El Aleem Ali Ali El‐Remaily,

Moumen S. Kamel

et al.

Materials Science in Semiconductor Processing, Journal Year: 2024, Volume and Issue: 188, P. 109201 - 109201

Published: Dec. 10, 2024

Language: Английский

Design and DFT calculations of optoelectronic material based on thiazolobenzimidazole-coupled isatin derivatives DOI
Rabab S. Jassas, Omran A. Omran, Aly Abdou

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 325, P. 129689 - 129689

Published: July 9, 2024

Language: Английский

Citations

9
Optical characterization of MoS2 and MoS2/Zn synthesized by thermal evaporation and sol-gel spin-coating techniques for gas-sensing and NLO-applications DOI

E. Kh. Shokr,

H.M. Ali,

Heba A. Mohamed

et al.

Physica B Condensed Matter, Journal Year: 2024, Volume and Issue: 683, P. 415936 - 415936

Published: April 5, 2024

Language: Английский

Citations

7
Design, spectroscopic characterizations, and biological investigation of oxospiro[chromine-4,3-indolene]-based compounds as promising antiproliferative EGFR inhibitors and antimicrobial agents DOI
Abdullah Yahya Abdullah Alzahrani,

Moustafa O. Aboelez,

Moumen S. Kamel

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: 29(1), P. 471 - 487

Published: June 9, 2024

Language: Английский

Citations

5
High Nonlinear Optical Performance of p-Tert-Butylthiacalix arene Derivatives: Synthesis, Characterization, and Theoretical Validation DOI
Mohammed B. Hawsawi, Omran A. Omran, Aly Abdou

et al.

Optical Materials, Journal Year: 2025, Volume and Issue: unknown, P. 116642 - 116642

Published: Jan. 1, 2025

Language: Английский

Citations

0
Integrating GWAS and Transcriptome Data through PrediXcan and Multimodal Deep Learning to Reveal Genetic Basis and Novel Drug Repositioning Opportunities for Alzheimer's Disease DOI Open Access

Xuecong Tian,

Ying Su, Sizhe Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Alzheimer’s Disease (AD) is the leading cause of dementia, imposing significant economic and social burdens. Although genome-wide association studies (GWAS) have identified approximately 70 risk loci, functional mechanisms underlying AD remain unclear. In this study, we integrated GWAS summary statistics from Jiang et al. with gene expression data GTEx project using S-PrediXcan method, encompassing 61 brain-related traits across 49 tissues. Comprehensive analysis five traits, including family history AD, highlighted key genes such as APOE, APOC1, TOMM40, which play crucial roles in cholesterol metabolism, immune response, neuroinflammation. Validation ROSMAP dataset confirmed these phenotypes. Furthermore, developed AD-MIF, a novel deep multi-layer information fusion model that integrates multi-omics data, achieving 10-20% improvement AUC performance for predicting AD-related compared to traditional models. Gene enrichment emphasized importance pathways metabolism response pathogenesis AD. Additionally, drug repositioning candidate drugs, Dasatinib Sirolimus, may alleviate progression by reducing neuroinflammation clearing senescent cells. Our findings advance understanding genetic architecture improve predictive models, propose potential therapeutic drugs.

Language: Английский

Citations

0
Synthesis, optical linear and non-linear characterization and metal ion sensing application of some novel thieno[2,3-b]thiophene-2,5-dicarbohydrazide Schiff base derivatives DOI Creative Commons
A. M. Soliman, Mahmoud Abd El Aleem Ali Ali El‐Remaily,

Moumen S. Kamel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 10, 2025

Abstract Synthesized 3,4-Diaminothieno[2,3-b]thiophene-2,5-dicarbohydrazide (DTT) Schiff base derivatives newly were synthesized by attaching with different aldehydes, deposited in thin film form thermal evaporation technique, and characterized UV–Visible-NIR spectroscopy, FT-IR, NMR, elemental analysis. It is revealed that compound 4 has the highest absorption peak intensity at 586 nm. The allied absorption, dielectric, dispersion parameters have been calculated discussed. obtained results manifested DTT lower (1.92 eV), higher (3.47 eV) energy band gap values, respectively, as a result of conjugation number effect. high nonlinear refractive index n 2 third-order susceptibility χ (3) these organic films are comparable those chalcogenide oxide materials, making them promising for optical systems. Compound displays sensitivity towards metal ion detection (ex. Cu +2 , Ni Fe +3 Mn Pb Co ), suggesting its ability to be applied sensor quantifying their concentration levels means suitable calibration curve.

Language: Английский

Citations

0
Discovery of new thiazolidin-4-one and thiazole nucleus incorporation sulfaguanidine scaffold as new class of antimicrobial agents: Design, synthesis, in silico ADMET, and docking simulation DOI

Ola A. Abu Ali,

Ahmed Ragab, Yousry A. Ammar

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141879 - 141879

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis, characterization, and study of linear and non-linear optical properties of some newly thieno[2,3-b]thiophene analogs DOI
Hany M. Abd El‐Lateef,

Moumen S. Kamel,

Abdullah Yahya Abdullah Alzahrani

et al.

Semiconductor Science and Technology, Journal Year: 2024, Volume and Issue: 39(12), P. 125014 - 125014

Published: Nov. 5, 2024

Abstract New 3,4-diaminothieno[2,3-b]thiophene derivatives were synthesized by attaching with different aromatic have rich electron. The resulting compounds been investigated FT-IR, NMR, elemental analysis and optical absorption spectra. Comparison between the revealed that oxoindolin-3-ylidene)amino)thieno[2,3-b]thiophene has highest peak intensity at ∼ 696 nm . Thin films prepared thermal evaporation technique characterized UV-visible-NIR spectroscopy associated absorption, dielectric dispersion parameters compared other reported results. obtained results indicated diethyl 3,4-bis(((E)-2-oxoindolin-3-ylidene)amino)thieno[2,3-b]thiophene-2,5-dicarboxylate 3,4-bis(((E)-2-oxoindolin-3-ylidene)amino)thieno[2,3-b]thiophene-2,5-dicarbonitrile manifested small band energy gap 1.95 eV 1.66 eV, respectively, as a result of increasing conjugation high coefficient, making these ideal for use in solar cells. nonlinear such refractive index third-order susceptibility organic compound thin are significantly asymptotic to chalcogenide oxide materials, them suitable devices.

Language: Английский

Citations

3
New S- and N-alkyl functionalized bis-1,2,4-Triazolyl-based Derivatives as Potential Dual EGFRWT and EGFRT790M Inhibitors: Synthesis, Anti-proliferative Evaluation, Molecular Docking Study and ADMET Studies DOI

A. M. I. Ahmed,

Moustafa O. Aboelez,

Hend A. A. Ezelarab

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140720 - 140720

Published: Nov. 1, 2024

Language: Английский

Citations

0
Optoelectronic characterizations, and RT-NH3 gas sensing application of newly synthesized spiro[indoline-3,4′-pyrano[2,3-b]pyridine]derivative DOI

E. Kh. Shokr,

Mahmoud Abd El Aleem Ali Ali El‐Remaily,

Moumen S. Kamel

et al.

Materials Science in Semiconductor Processing, Journal Year: 2024, Volume and Issue: 188, P. 109201 - 109201

Published: Dec. 10, 2024

Language: Английский

Citations

0