A Comprehensive Evaluation of the Neuropharmacological Potential of Methanolic Leaf Extract of Acanthus ebracteatus (Vahl.) Using Experimental and In Silico Approaches DOI Open Access
Md. Aktaruzzaman, Md. Tarikul Islam, Md. Aktaruzzaman

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT This study was undertaken to assess the antioxidant and neuropharmacological potentials of methanol leaf extract Acanthus ebracteatus (MAEL) through experimental in silico methods. The phytochemical screening (PS) GC–MS (gas chromatography–mass spectrometry) identified 28 phytochemicals with different classes nature MAEL. MAEL revealed better activity various vitro assays. Additionally, tail suspension test (TST) forced swimming (FST), a dose‐dependent reduction immobility time observed indicating antidepressant activity. In elevated plus maze (EPM), led increased spent more entries open arms. At same time, hole board (HBT) demonstrated an increase head dipping compared control, both anxiolytic Moreover, locomotor activities field (OFT) cross (HCT). Molecular docking showed binding affinities two compounds, CID‐518982 CID‐236641. ADME/T analysis good drug likeliness no toxicity. Finally, simulation structural stability significant fluctuations compounds selected receptors. this study, CID‐236641 might serve as candidates for treating anxiety depression.

Language: Английский

A Comprehensive Evaluation of the Neuropharmacological Potential of Methanolic Leaf Extract of Acanthus ebracteatus (Vahl.) Using Experimental and In Silico Approaches DOI Open Access
Md. Aktaruzzaman, Md. Tarikul Islam, Md. Aktaruzzaman

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT This study was undertaken to assess the antioxidant and neuropharmacological potentials of methanol leaf extract Acanthus ebracteatus (MAEL) through experimental in silico methods. The phytochemical screening (PS) GC–MS (gas chromatography–mass spectrometry) identified 28 phytochemicals with different classes nature MAEL. MAEL revealed better activity various vitro assays. Additionally, tail suspension test (TST) forced swimming (FST), a dose‐dependent reduction immobility time observed indicating antidepressant activity. In elevated plus maze (EPM), led increased spent more entries open arms. At same time, hole board (HBT) demonstrated an increase head dipping compared control, both anxiolytic Moreover, locomotor activities field (OFT) cross (HCT). Molecular docking showed binding affinities two compounds, CID‐518982 CID‐236641. ADME/T analysis good drug likeliness no toxicity. Finally, simulation structural stability significant fluctuations compounds selected receptors. this study, CID‐236641 might serve as candidates for treating anxiety depression.

Language: Английский

Citations

1