Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases DOI Creative Commons
Christopher Vennard, Samson Marvellous Oladeji, Herman O. Sintim

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 663 - 663

Published: April 30, 2025

The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, dinucleotides (CDNs) oligonucleotides (cONs). Enzymes that cleave the (nucleases phosphodiesterases) play important roles cell persistence fitness have therefore become targets for various diseased states. While inhibitors been developed nucleases mononucleotide phosphodiesterases, some clinical successes, there a paucity of recently discovered phosphodiesterases or ring CDNs cONs. Inhibitors bacterial c-di-GMP c-di-AMP potential to be used anti-virulence compounds, while compounds inhibit degradation 3′,3′-cGAMP, cA3, cA4, cA6 could serve antibiotic adjuvants accumulation these second messengers leads abortive infection. In humans, 2′3′-cGAMP plays critical antiviral antitumor responses. ENPP1 (the phosphodiesterase) virally encoded dinucleotide poxin, however, blunt this response. poxin-like enzymes anticancer agents, respectively. This review summarizes efforts made towards discovery development CDN cON nucleases.

Language: Английский

Insight Study For Repurposing Of Certain Anti‐Inflammatory Drugs Based On Aspirin and Salicylic Acid Scaffolds For The Treatment of Cancer as CDKs Inhibitors: Cheminformatics and Anticancer Studies DOI
Mohnad Abdalla, Ahmed E. Elmasry, Mohamed T. M. Nemr

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract The highly increased and global mortality due to cancer has created an urgent need discover promising targets for its treatment. Where drug repurposing was considered as attractive approach that can facilitate the lead generation optimization phases of discovery by existing agents target diseases other than their primary uses. Cheminformatics studies represented in molecular docking well dynamic simulation salicylic acid / aspirin analogues sulindac indomethacin anti‐inflammatory drugs were carried out be used cyclin‐dependent kinases (CDKs) namely CDK2, CDK6, CDK12 inhibitors. Sulindac displayed best binding ligand all receptors. CDKs inhibition effects three sulindac, anthranilic demonstrated good inhibitory activity against ranging from 0.48 1.78 µM. Likewise, cytotoxicity revealed potent anticancer 0.155 1.278 µM cell lines: HCT‐116, MCF‐7, HeLa cells. As a result, this technique saves lot time money order new agents.

Language: Английский

Citations

1
Preparation and Characterization of Tadalafil-loaded Hydrogel: An in-vivo Evaluation of Wound Healing Activity DOI Creative Commons

Anita Sadat Haji Seyed Javadi Pajouhi,

Amir Larki-Harcheghani,

Mojdeh Mohammadi

et al.

Pharmaceutical Science Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100066 - 100066

Published: Feb. 1, 2025

Language: Английский

Citations

0
Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases DOI Creative Commons
Christopher Vennard, Samson Marvellous Oladeji, Herman O. Sintim

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 663 - 663

Published: April 30, 2025

The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, dinucleotides (CDNs) oligonucleotides (cONs). Enzymes that cleave the (nucleases phosphodiesterases) play important roles cell persistence fitness have therefore become targets for various diseased states. While inhibitors been developed nucleases mononucleotide phosphodiesterases, some clinical successes, there a paucity of recently discovered phosphodiesterases or ring CDNs cONs. Inhibitors bacterial c-di-GMP c-di-AMP potential to be used anti-virulence compounds, while compounds inhibit degradation 3′,3′-cGAMP, cA3, cA4, cA6 could serve antibiotic adjuvants accumulation these second messengers leads abortive infection. In humans, 2′3′-cGAMP plays critical antiviral antitumor responses. ENPP1 (the phosphodiesterase) virally encoded dinucleotide poxin, however, blunt this response. poxin-like enzymes anticancer agents, respectively. This review summarizes efforts made towards discovery development CDN cON nucleases.

Language: Английский

Citations

0