Coumarin hybrids: a sighting of their roles in drug targeting

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(10), P. 5753 - 5772

Published: May 20, 2024

Language: Английский

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Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1462 - 1462

Published: Nov. 28, 2024

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes

Language: Английский

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Chili pepper: A delve into its nutritional values and roles in food-based therapy

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100928 - 100928

Published: Feb. 16, 2025

Language: Английский

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Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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Maternal lactoferrin supplementation prevents mitochondrial and redox homeostasis dysfunction, and improves antioxidant defenses through Nrf2 and UCP2 signaling after neonatal hypoxia-ischemia

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Intersecting molecular pathways in Synucleinopathies and Amyloidogenesis: Exploring shared mechanisms and therapeutic potential

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149568 - 149568

Published: March 1, 2025

Language: Английский

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Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(3)

Published: Oct. 30, 2023

Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α, nuclear receptor plays key role in regulating lipid metabolism. Gem used lower the levels of triglycerides and reduce risk coronary heart disease patients. Experimental studies vitro vivo have can prevent or slow progression neurological disorders (NDs), including cerebral ischemia (CI), Alzheimer's (AD), Parkinson's (PD), multiple sclerosis (MS). Neuroinflammation known play significant these disorders. Method The literature review for this study was conducted by searching Scopus, Science Direct, PubMed, Google Scholar databases. Result results show neuroprotective effects through several cellular molecular mechanisms such as: (1) ability upregulate pro‐survival factors (PGC‐1α TFAM), promoting survival function mitochondria brain, (2) strongly inhibits activation NF‐κB, AP‐1, C/EBPβ cytokine‐stimulated astroglial cells, which are increase expression iNOS production NO response proinflammatory cytokines, (3) protects dopamine neurons MPTP mouse model PD increasing PPARα, turn stimulates GDNF astrocytes, (4) reduces amyloid plaque pathology, activity glial improves memory, (5) increases myelin genes (MBP CNPase) via PPAR‐β, (6) hippocampal BDNF counteract depression. Conclusion According study, investigated its potential therapeutic effect NDs. Further research needed fully understand

Language: Английский

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Sweet Bell Pepper: A Focus on Its Nutritional Qualities and Illness-Alleviated Properties

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(4), P. 459 - 469

Published: Dec. 9, 2023

Language: Английский

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Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents: A narrative review

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(3), P. 195 - 207

Published: May 29, 2024

Abstract Glaucoma, an irreversible optic neuropathy, primarily affects retinal ganglion cells (RGC) and causes vision loss blindness. The damage to RGCs in glaucoma occurs by various mechanisms, including elevated intraocular pressure, oxidative stress, inflammation, other neurodegenerative processes. As the disease progresses, of leads loss. Therefore, protecting from promoting their survival are important goals managing glaucoma. In this regard, resveratrol (RES), a polyphenolic phytoalexin, exerts antioxidant effects slows down evolution progression present review shows that RES plays protective role cases ischemic injury hypoxia as well ErbB2 protein expression retina. Additionally, roles cell growth, reducing apoptosis, decreasing stress H 2 O ‐exposed RGCs. was also found inhibit suppress activation mitogen‐activated kinase signaling pathways. could alleviate function impairment suppressing hypoxia‐inducible factor‐1 alpha/vascular endothelial growth factor p38/p53 axes while stimulating PI3K/Akt pathway. might exert potential therapeutic for survival.

Language: Английский

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Antioxidant and neuroprotection properties are involved in the anti-Parkinson potential of plumbagin and resveratrol in rotenone-induced Parkinson-like conditions

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131

Published: Jan. 1, 2025

Language: Английский

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