Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)
Published: Nov. 25, 2024
Language: Английский
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Dec. 4, 2024
The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha (HIF1α) and influencing network hypoxia-driven pathways within tumor microenvironment (TME). SMURF2 targets HIF1α for ubiquitination subsequent proteasomal degradation, disrupting hypoxic responses that promote cell survival, metabolic reprogramming, angiogenesis, resistance to therapy. Beyond its role regulation, exerts extensive control over cellular processes central progression, including chromatin remodeling, DNA damage repair, ferroptosis, stress responses. Notably, SMURF2's ability ferroptotic death through GSTP1 degradation offers an alternative pathway overcome apoptosis resistance, expanding therapeutic options refractory cancers. This review delves into multifaceted interactions between HIF1α, emphasizing how their interplay impacts adaptations like Warburg effect, immune evasion, resistance. We discuss dual functionality both suppressor and, certain contexts, oncogenic factor, underscoring potential highly versatile target. Furthermore, SMURF2-HIF1α axis presents innovative approach destabilize hypoxia-dependent pathways, sensitizing tumors chemotherapy, radiotherapy, immune-based treatments. However, complexity necessitate thorough assessment off-target effects challenges specificity, which must be addressed optimize clinical application. concludes by proposing future directions research pathway, aiming refine targeted strategies exploit this address adaptive mechanisms aggressive tumors, ultimately advancing landscape precision oncology.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 4, 2024
Background Lymphangiogenesis (LYM) has an important role in tumor progression and is strongly associated with metastasis. However, the clinical application of LYM not progressed as expected. The potential value needs to be further developed lung adenocarcinoma (LUAD) patients. Methods Sequencing data characteristics LUAD patients were downloaded from Cancer Genome Atlas GEO databases. Multiple machine learning algorithms used screen feature genes develop index. Immune cell infiltration, immune checkpoint expression, Tumor Dysfunction Exclusion (TIDE) algorithm drug sensitivity analysis explore correlation index profile anti-tumor therapy. Results We screened four lymphangiogenic (PECAM1, TIMP1, CXCL5 PDGFB) construct based on multiple algorithms. divided into high group low median a risk factor for prognosis In addition, there was significant difference between groups. seemed benefit more immunotherapy results TIDE algorithm. Conclusion Overall, we confirmed that prognostic valuable predictor response patients, which provides new evidence LYM.
Language: Английский
Citations
1
European Urology Focus, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
1
Cancer Immunology Research, Journal Year: 2024, Volume and Issue: 13(2), P. 258 - 272
Published: Nov. 15, 2024
Abstract NK cell tumor infiltration is associated with good prognosis in patients metastatic castration-resistant prostate cancer (mCRPC). cells recognize and kill targets by a process called natural cytotoxicity. We hypothesized that promoting an antigen-specific synapse coactivation may enhance function mCRPC. describe tri-specific killer engager (TriKE) construct engages the activating receptor CD16 on prostate-specific membrane antigen (PSMA) mCRPC has IL15 moiety essential for survival, proliferation, priming. show PSMA TriKE specifically binds to PSMA-expressing significantly enhances expansion, degranulation, cytokine production of derived from healthy donors or cancer. Bystander killing PSMA-negative was also achieved treatment when cocultured PSMA-positive cells, suggesting potential benefit controlling escape. When tested under physiologic conditions recapitulating microenvironment, treated prolonged exposure hypoxia myeloid-derived suppressor maintained their potent whereas IL15-treated showed greatly impaired Finally, vivo testing improved control survival mice as compared untreated groups. In conclusion, demonstrates new therapy advanced providing additional signals maximize antitumor cancer, especially setting hostile microenvironment.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1592 - 1592
Published: Dec. 12, 2024
HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, stability increases, avoiding PHD and VHL protein-mediated degradation, which promotes its accumulation cells then activates gene expressions related to calcification. Additionally, modulates metabolic state by regulating pathways that govern switch between glycolysis oxidative phosphorylation, thereby further advancing process. The interaction other signaling pathways, such as nuclear factor-κB, Notch, Wnt/β-catenin, creates complex network serves critical driving force VC. Therefore, deeper understanding mechanism during development progression VC is great significance, it not only key molecular marker for pathological mechanisms but also represents promising target future anti-calcification therapies.
Language: Английский
Citations
1
Anticancer Research, Journal Year: 2024, Volume and Issue: 44(9), P. 3697 - 3712
Published: Aug. 28, 2024
The transcription factor hypoxia inducible factor-1 (HIF-1) is one of the main factors in cell's response to a lack oxygen. Hypoxia typical feature growing cancerous tumor. Increased activity HIF-1 observed many cancers, including endometrial cancer. functions as heterodimer consisting three subunits HIF-1α, HIF-2α, and HIF-3α subunit β. HIF-1α that sensitive oxygen concentration constitutively expressed. gene highly polymorphic. Literature data suggest single nucleotide polymorphisms (SNPs) may be risk for A better understanding molecular mechanisms cancer development, progression prognosis, role SNPs, could lead development new anti-cancer therapies.
Language: Английский
Citations
1
Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)
Published: Nov. 25, 2024
Language: Английский
Citations
0