Impact of sex and complex PTSD comorbidity on pharmacological treatment response in bipolar disorder patients

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111337 - 111337

Published: March 1, 2025

Language: Английский

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Tracking brain maturation in vivo: functional connectivity, white matter integrity, and synaptic density in developing mice

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105720 - 105720

Published: April 18, 2025

Language: Английский

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Antidepressant- and Anxiolytic-like Effects of Pomegranate: Is It Acting by Common or Well-Known Mechanisms of Action?

Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2205 - 2205

Published: Aug. 9, 2024

The pharmacological effects of pomegranates have been described considering metabolic aspects such as hypoglycemic and hypolipidemic activities. pomegranate extract has activity on the central nervous system (CNS) a natural antidepressant anxiolytic. chemical composition is complex since bioactive compounds are multiple secondary metabolites that identified in extracts derived from peel, seed, flowers, leaves, or their combination; so, it not easy to identify an individual compound responsible for its observed properties. From this point view, present review analyzes crude fractions possible mechanisms action concerning antidepressant- anxiolytic-like animal models. Serotonin receptors, estrogen peroxisome proliferator-activated receptor gamma (PPARγ), monoamine oxidase enzymes, well potent antioxidant neuroplasticity properties, mediators involved behaviors after treatment. CNS experimental models associated with specific stress level suggest could simultaneously modulate response by activating several targets. For review, scientific evidence was gathered integrate pathway be pomegranate's effects. Furthermore, potential benefits discussed comorbid conditions anxiety depression, perimenopause transition pain.

Language: Английский

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Severe menopausal symptoms linked to cognitive impairment: an exploratory study

Menopause The Journal of The North American Menopause Society, Journal Year: 2024, Volume and Issue: 31(11), P. 959 - 965

Published: Aug. 13, 2024

To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women.

Language: Английский

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Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin release factor and estrogen regulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 14, 2024

Cholinergic interneurons (ChIs) act as master regulators of striatal output, finely tuning neurotransmission to control motivated behaviors. ChIs are a cellular target many peptide and hormonal neuromodulators, including corticotropin releasing factor, opioids, insulin leptin, which can influence an animal's behavior by signaling stress, pleasure, pain nutritional status. However, little is known about how sex hormones via estrogen receptors the function these other neuromodulators. Here, we performed in situ hybridization on mouse tissue characterize effect choline acetyltransferase (

Language: Английский

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Exposure to 1-nitropyrene after weaning induces anxiety-like behavior partially by inhibiting steroid hormone synthesis in prefrontal cortex

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 475, P. 134911 - 134911

Published: June 13, 2024

Language: Английский

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Tracking Brain Maturation in Vivo: Functional Connectivity, White Matter Integrity, and Synaptic Density in Developing Mice

Published: Jan. 1, 2024

Language: Английский

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