Advances in cell therapy for orthopedic diseases: bridging immune modulation and regeneration

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Orthopedic diseases pose significant challenges to public health due their high prevalence, debilitating effects, and limited treatment options. Additionally, orthopedic tumors, such as osteosarcoma, chondrosarcoma, Ewing sarcoma, further complicate the landscape. Current therapies, including pharmacological treatments joint replacement, address symptoms but fail promote true tissue regeneration. Cell-based which have shown successful clinical results in cancers other diseases, emerged a promising solution repair damaged tissues restore function tumors. This review discusses advances potential application of cell therapy for with particular focus on osteoarthritis, bone fractures, cartilage degeneration, We explore mesenchymal stromal cells (MSCs), chondrocyte transplantation, engineered immune induced pluripotent stem enhance regeneration by modulating response addressing inflammation. Ultimately, integration cutting-edge therapy, modulation, molecular targeting strategies could revolutionize providing hope patients seeking long-term solutions conditions.

Language: Английский

The Effect of Adipose-Derived Stem Cell (ADSC)-Exos on the Healing of Autologous Skin Grafts in Miniature Pigs

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 479 - 479

Published: Jan. 8, 2025

The skin functions as the body's primary defense barrier; when compromised, it can lead to dehydration, infection, shock, or potentially life-threatening conditions. Miniature pigs exhibit characteristics and healing processes highly analogous humans. Mesenchymal stem cells contribute injury repair through a paracrine mechanism involving exosomes. This research examines whether adipose-derived MSC exosomes effectively enhance following autologous grafting in miniature pigs. It also compares roles distinctions of ADSCs ADSC-Exos inflammatory responses tissue regeneration. study found significantly reduced levels oxidative stress products pro-inflammatory factors, while antioxidant anti-inflammatory pro-regenerative factors were elevated, anti-regenerative factor decreased. Moreover, expression key markers-namely, PI3K, Akt, mTOR-in regeneration-associated signaling pathway increased. alterations these indicators indicate that regulate promote provides novel theoretical foundation for implementation acellular therapy clinical settings.

Language: Английский