Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis DOI Creative Commons
Chipeng Guo, Yuhong Tang, Ling Zeng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract The hyperactivation of autoreactive B cells and plasma leads to the development systemic lupus erythematosus (SLE) rheumatoid arthritis (RA), therefore, targeting abnormal might hold promise for treatment these refractory relapsing diseases. This study developed l ipid n ano p article‐encapsulated mRN A‐encoding a nti b odies (mRNab‐LNPs) CD19, evaluated their therapeutic efficacy in RA mice. mRNab‐LNPs enabled robust production anti‐CD19 antibodies multiple cell lines vitro. Interestingly, intramuscular injection resulted high sustained In particular, numbers CD19+ circulating tissue‐resident are significantly reduced by As result, histopathological changes tissue injuries both Collectively, findings demonstrate translational potential SLE RA.

Language: Английский

Citations

0
Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment DOI Creative Commons
Jiadai Tang, Lixin Chen, Xin Shen

et al.

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

Citations

0