Metformin-induced RBMS3 expression enhances ferroptosis and suppresses ovarian cancer progression DOI Creative Commons

Yue Zhao,

Yixiao Wang, Xinyi Zhang

et al.

Reproductive Biology, Journal Year: 2024, Volume and Issue: 25(1), P. 100968 - 100968

Published: Dec. 16, 2024

Language: Английский

In vitro study of the pro-apoptotic mechanism of amino acid Schiff base copper complexes on anaplastic thyroid cancer DOI
Peiran Zhao, Xinyan Zhang,

Jianfang Dong

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 206, P. 107005 - 107005

Published: Jan. 11, 2025

Language: Английский

Citations

1

Production of Biofuels from Agricultural Waste DOI Open Access
Francis Mekunye,

Peter Makinde

Asian Journal of Agricultural and Horticultural Research, Journal Year: 2024, Volume and Issue: 11(3), P. 37 - 49

Published: July 15, 2024

Agricultural waste represents a largely untapped resource that could be utilized for the production of biofuels through various conversion pathways. As global demand renewable and sustainable energy grows, offer solutions to mitigate climate change impacts while improving management. This review analyzes using agricultural residues by-products as feedstocks biofuel biological, thermochemical chemical processes. The different types lignocellulosic biomass available from activities are discussed, along with their compositions. While has advantages like wide availability low cost, challenges relating heterogeneous composition, pre-existing contamination seasonal must addressed. Fermentation, anaerobic digestion, pyrolysis gasification examined established routes converting into liquid biogas. Pretreatment methods, enzyme pathways synthesis fuels ethanol, butanol diesel substitutes outlined. Environmental benefits waste, including greenhouse gas mitigation recycling soil nutrients, evaluated against fossil fuel alternatives. Case studies on operational plants feasibility provide insights technical economic viability at scale. Challenges regarding feedstock logistics, efficiency, commercial scale-up sustainability assessment identified future research focus. In conclusion, finds is promising when integrated appropriate thermochemical, biochemical or digestion technologies. field advancing, further improvements in areas such supply, pretreatment technologies, demonstration will critical realize full potential this emerging bioeconomy sector. recommends steps accelerate commercialization policy frameworks incentivize waste-to-energy solutions.

Language: Английский

Citations

1

Anti-Diabetic Therapies and Cancer: From Bench to Bedside DOI Creative Commons
Dimitris Kounatidis, Natalia G. Vallianou, Ιrene Karampela

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1479 - 1479

Published: Nov. 20, 2024

Diabetes mellitus (DM) is a significant risk factor for various cancers, with the impact of anti-diabetic therapies on cancer progression differing across malignancies. Among these therapies, metformin has gained attention its potential anti-cancer effects, primarily through modulation AMP-activated protein kinase/mammalian target rapamycin (AMPK/mTOR) pathway and induction autophagy. Beyond metformin, other conventional treatments, such as insulin, sulfonylureas (SUs), pioglitazone, dipeptidyl peptidase-4 (DPP-4) inhibitors, have also been examined their roles in biology, though findings are often inconclusive. More recently, novel medications, like glucagon-like peptide-1 (GLP-1) receptor agonists, dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) sodium-glucose co-transporter-2 (SGLT-2) revolutionized DM management by not only improving glycemic control but delivering substantial cardiovascular renal benefits. Given diverse metabolic including anti-obesogenic properties, agents now under meticulous investigation influence tumorigenesis advancement. This review aims to offer comprehensive exploration evolving landscape glucose-lowering treatments implications biology. It critically evaluates experimental evidence surrounding molecular mechanisms which medications may modulate oncogenic signaling pathways reshape tumor microenvironment (TME). Furthermore, it assesses translational research clinical trials gauge practical relevance real-world settings. Finally, explores adjuncts treatment, particularly enhancing efficacy chemotherapy, minimizing toxicity, addressing resistance within framework immunotherapy.

Language: Английский

Citations

0

Metformin-induced RBMS3 expression enhances ferroptosis and suppresses ovarian cancer progression DOI Creative Commons

Yue Zhao,

Yixiao Wang, Xinyi Zhang

et al.

Reproductive Biology, Journal Year: 2024, Volume and Issue: 25(1), P. 100968 - 100968

Published: Dec. 16, 2024

Language: Английский

Citations

0