Regulatory effect of Wnt signaling on mitochondria in cancer: from mechanism to therapy
Jing Han,
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Yimeng Yuan,
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Jianhua Zhang
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et al.
APOPTOSIS,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
Cancer
is
one
of
the
most
significant
public
health
challenges
in
new
millennium,
and
complex
mechanisms
are
at
work
to
contribute
its
pathogenesis
progression.
The
Wnt
signaling
pathways,
which
crucial
conserved
cascades
involved
embryological
development
tissue
homeostasis,
mitochondria,
intracellular
powerhouses
responsible
for
energy
production,
calcium
iron
as
well
mitochondrial
apoptosis
eukaryotic
cells,
have
their
own
regulating
these
pathological
processes.
In
past
decade,
accumulating
evidence
has
indicated
that
pathways
directly
regulate
biogenesis
function
under
physiological
conditions.
this
review,
we
systemically
summarize
current
understanding
how
particularly
canonical
cascade,
fission,
respiration,
metabolism,
mitochondrial-dependent
cancer.
addition,
discuss
recent
advancements
research
anticancer
agents
related
pharmacological
targeting
transduction
pathway
and/or
function.
We
believe
combined
use
pharmaceuticals
mitochondria
with
conventional
therapies,
immunotherapy
targeted
therapy
based
on
accurate
molecular
diagnosis
will
undoubtedly
be
future
mainstream
direction
personalized
cancer
treatment,
could
benefit
more
patients.
Language: Английский
The Wnt/Pyruvate kinase, Muscle axis plays an essential role in the differentiation of mouse neuroblastoma cells
Neurochemistry International,
Journal Year:
2024,
Volume and Issue:
181, P. 105901 - 105901
Published: Nov. 13, 2024
Language: Английский
Targeting Glycolytic Reprogramming in Cholangiocarcinoma: A Novel Approach for Metabolic Therapy
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 9665 - 9681
Published: Nov. 1, 2024
Cholangiocarcinoma
(CCA)
is
a
highly
aggressive
and
poorly
prognostic
tumor.
Due
to
the
lack
of
early
symptoms,
diagnosing
CCA
remains
challenging,
often
occurring
at
an
advanced
stage.
Therefore,
exploring
underlying
mechanisms
development
identifying
potential
biomarkers
therapeutic
targets
crucial.
Recently,
metabolic
reprogramming
in
cancer
cells
has
emerged
as
hallmark
disease.
Glycolysis
been
identified
central
component
CCA,
with
multiple
signaling
pathways
key
enzymes
playing
significant
roles.
Additionally,
non-coding
RNAs
(ncRNAs)
post-translational
modifications
proteins
are
also
involved
regulating
glycolysis
CCA.
In
this
review,
we
provide
comprehensive
summary
alterations
metabolism
diverse
involved,
they
might
exert
impact
on
Overall,
targeting
holds
considerable
promise
crucial
strategy
for
enhancing
outcomes
addition,
performed
bioinformatic
analysis
relationship
between
identify
investigate
targets.
The
purpose
study
theoretical
basis
Language: Английский