Electroacupuncture regulates ferroptosis to improve postoperative cognitive dysfunction in mice through mediating GRX1/GSK-3β/Nrf2 axis

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111234 - 111234

Published: Jan. 1, 2025

The incidence of postoperative cognitive dysfunction (POCD) is higher happening in the elderly. It has been reported electroacupuncture (EA) was beneficial to treatment POCD, but its specific regulatory mechanism still unclear. Through partial hepatectomy mice, POCD model mice established. Baihui acupoint (GV20) selected for targeted point EA therapy. Morris water maze (MWM) applied evaluate impairment mice. HE staining used examine cell arrangement and morphology hippocampus RT-qPCR, western blot IHC were employed detect abundance genes proteins. MDA, GSH iron levels measured by some commercial kits. Our findings revealed that surgery impaired learning memory ability promoted ferroptosis. inhibited GRX1 inactivated GSK-3β/Nrf2 pathway. However, therapy abolished these effects. In addition, silencing erastin EA-mediated alterations improving suppressed ferroptosis regulating GRX1/GSK-3β/Nrf2 pathway improve

Language: Английский

The potential of natural herbal plants in the treatment and prevention of non-small cell lung cancer: An encounter between ferroptosis and mitophagy

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119555 - 119555

Published: Feb. 1, 2025

Language: Английский