Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases DOI Creative Commons
Anna Długosz, Błażej Błaszak, Damian Czarnecki

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 694 - 694

Published: Feb. 5, 2025

Xanthohumol (XN), a bioactive plant flavonoid, is an antioxidant, and as such, it exhibits numerous beneficial properties, including anti-inflammatory, antimicrobial, antioxidative effects. The main dietary source of XN beer, where introduced through hops. Although the concentration in beer low, large quantities hop-related post-production waste present opportunity to extract residues for technological or pharmaceutical purposes. presented study focuses on role prevention neurodegenerative diseases, analyzing its effect at molecular level signal transduction metabolism. paper brings up XN’s mechanism action, potential effects, experimental clinical studies Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). Additionally, challenges future research directions XN, bioavailability, safety, tolerance, have been discussed.

Language: Английский

Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases DOI Creative Commons
Anna Długosz, Błażej Błaszak, Damian Czarnecki

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 694 - 694

Published: Feb. 5, 2025

Xanthohumol (XN), a bioactive plant flavonoid, is an antioxidant, and as such, it exhibits numerous beneficial properties, including anti-inflammatory, antimicrobial, antioxidative effects. The main dietary source of XN beer, where introduced through hops. Although the concentration in beer low, large quantities hop-related post-production waste present opportunity to extract residues for technological or pharmaceutical purposes. presented study focuses on role prevention neurodegenerative diseases, analyzing its effect at molecular level signal transduction metabolism. paper brings up XN’s mechanism action, potential effects, experimental clinical studies Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). Additionally, challenges future research directions XN, bioavailability, safety, tolerance, have been discussed.

Language: Английский

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