Assessing the Association Between Gadolinium-Based Contrast Agents and Parkinson Disease: Insights From the Korean National Health Insurance Service Database

Investigative Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Objectives This study aimed to investigate the association between use of linear and macrocyclic gadolinium-based contrast agents (GBCAs) subsequent development Parkinson disease (PD). Methods In this retrospective cohort study, data were extracted from Korean National Health Insurance Service database, comprising 1,038,439 individuals. From population, 175,125 adults aged 40 60 years with no history brain identified. All patients including 3835 who administered GBCA at least once monitored until 2022 for onset PD. Propensity score (PS) matching was employed compare incidence PD those exposed GBCAs (either or macrocyclic) not (no-GBCA group). Results The final consisted 1175 subjects GBCAs, 2334 171,616 unexposed any After PS matching, significantly higher in group compared no-GBCA (0.9% vs 0.0%, P = 0.002) also than (0.5% 0.04%, 0.003). No significant difference observed groups. Conclusions Exposure linked an increased risk developing large population-based study. did differ GBCAs.

Language: Английский

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Investigative Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025