Enhancing the efficacy of Zinc Oxide Nanoparticles by Beta-carotene conjugation for improved anti-microbial and anti-tumor therapy for Dental Application DOI
Mohammed Rafi Shaik, Siva Prasad Panda, Shaik Althaf Hussain

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 34

Published: Dec. 31, 2024

The increasing prevalence of dental pathogens and oral cancer calls for new therapeutic agents. Nanoparticle (NPs) based tumor therapy enables precise targeting controlled drug release, improving anti-cancer treatment efficacy while reducing systemic toxicity. Zinc oxide NPs (ZnO NPs) are notable in nanomedicine their exceptional physicochemical biological properties. This study synthesizes characterizes beta-carotene-coated ZnO (BT-ZnO potential antimicrobial applications, demonstrating significant against cells. Scanning Electron Microscopy, EDAX, UV, FTIR, XRD, Zeta analysis prepared BT-ZnO revealed uniform flower-like crystalline structures with intricate morphology an average particle size 38.06 nm. FTIR spectra identified various functional groups, suggesting a complex organic compound coated NPs. measurements showed pH-dependent surface charge variations, which crucial understanding colloidal stability. activity was potent pathogens, minimum inhibitory concentration (MIC) values 50 µg/mL highlighting inhibition. Molecular docking studies demonstrated strong binding affinities BT to key receptor proteins pathogens. exhibited antioxidant 68%, comparable ascorbic acid, anti-inflammatory effects 75.1% at 100 µg/mL. Cytotoxicity assays indicated concentration-dependent suppression KB cell proliferation, decreasing viability 37.19%, gene expression elevated P53 expression, apoptotic response. These multifaceted properties underscore the as integrated approach healthcare oncology.

Language: Английский

Exploring the potential of fish bone peptides: a natural approach to enhancing oral health DOI

Taniya Mary Martin,

Ajay Guru

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 2

Published: Dec. 3, 2024

Language: Английский

Citations

0
Enhancing the efficacy of Zinc Oxide Nanoparticles by Beta-carotene conjugation for improved anti-microbial and anti-tumor therapy for Dental Application DOI
Mohammed Rafi Shaik, Siva Prasad Panda, Shaik Althaf Hussain

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 34

Published: Dec. 31, 2024

The increasing prevalence of dental pathogens and oral cancer calls for new therapeutic agents. Nanoparticle (NPs) based tumor therapy enables precise targeting controlled drug release, improving anti-cancer treatment efficacy while reducing systemic toxicity. Zinc oxide NPs (ZnO NPs) are notable in nanomedicine their exceptional physicochemical biological properties. This study synthesizes characterizes beta-carotene-coated ZnO (BT-ZnO potential antimicrobial applications, demonstrating significant against cells. Scanning Electron Microscopy, EDAX, UV, FTIR, XRD, Zeta analysis prepared BT-ZnO revealed uniform flower-like crystalline structures with intricate morphology an average particle size 38.06 nm. FTIR spectra identified various functional groups, suggesting a complex organic compound coated NPs. measurements showed pH-dependent surface charge variations, which crucial understanding colloidal stability. activity was potent pathogens, minimum inhibitory concentration (MIC) values 50 µg/mL highlighting inhibition. Molecular docking studies demonstrated strong binding affinities BT to key receptor proteins pathogens. exhibited antioxidant 68%, comparable ascorbic acid, anti-inflammatory effects 75.1% at 100 µg/mL. Cytotoxicity assays indicated concentration-dependent suppression KB cell proliferation, decreasing viability 37.19%, gene expression elevated P53 expression, apoptotic response. These multifaceted properties underscore the as integrated approach healthcare oncology.

Language: Английский

Citations

0