Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment DOI Open Access
Li Zhu,

Lin Tang,

Kang Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3261 - 3261

Published: April 1, 2025

Sheep (Ovis aries), domesticated from wild Asian mouflon ~10,000 years ago, are an important livestock species adapted to various ecological environments. Recent advancements in high-throughput sequencing and global environmental databases have facilitated the exploration of genetic-environmental associations, uncovering genetic epigenetic mechanisms behind sheep's adaptation multiple Studies show that HIF-1α EPAS1 enhance high-altitude via hypoxic stress regulation; UCP1 contributes cold through non-shivering thermogenesis; SLC4A4 GPX3 increase drought resistance by regulating renal water reabsorption; SOCS2 likely plays a role metabolic response regulation. Additionally, sheep adapt temperature, drought, DNA methylation, transcriptional regulation (e.g., SOD1, GPX4), heat shock proteins HSP70), pathways UCP1). These findings offer valuable insights for improving breeding enhancement. This review summarizes high altitude, cold, heat, comprehensive climate stress.

Language: Английский

Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment DOI Open Access
Li Zhu,

Lin Tang,

Kang Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3261 - 3261

Published: April 1, 2025

Sheep (Ovis aries), domesticated from wild Asian mouflon ~10,000 years ago, are an important livestock species adapted to various ecological environments. Recent advancements in high-throughput sequencing and global environmental databases have facilitated the exploration of genetic-environmental associations, uncovering genetic epigenetic mechanisms behind sheep's adaptation multiple Studies show that HIF-1α EPAS1 enhance high-altitude via hypoxic stress regulation; UCP1 contributes cold through non-shivering thermogenesis; SLC4A4 GPX3 increase drought resistance by regulating renal water reabsorption; SOCS2 likely plays a role metabolic response regulation. Additionally, sheep adapt temperature, drought, DNA methylation, transcriptional regulation (e.g., SOD1, GPX4), heat shock proteins HSP70), pathways UCP1). These findings offer valuable insights for improving breeding enhancement. This review summarizes high altitude, cold, heat, comprehensive climate stress.

Language: Английский

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