Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: April 1, 2025
Language: Английский
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 31, 2025
Language: Английский
Citations
5
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 3, 2025
Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.
Language: Английский
Citations
1
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 18, 2025
Antibiotics represent one of the most significant medical breakthroughs twentieth century, playing a critical role in combating bacterial infections. However, rapid emergence antibiotic resistance has become major global health crisis, significantly complicating treatment protocols. This paper provides narrative review current state resistance, synthesizing findings from primary research and comprehensive articles to examine various mechanisms bacteria employ counteract antibiotics. One sources is improper use antibiotics livestock industry. The drug-resistant microorganisms human activities industrial production presented environmental public concerns. Today, resistant nosocomial infections occur following long-term hospitalization patients, causing death many people, so there an urgent need for alternative treatments. In response this non-antibiotic therapeutic strategies have been proposed, including bacteriophages, probiotics, postbiotics, synbiotics, fecal microbiota transplantation (FMT), nanoparticles (NPs), antimicrobial peptides (AMPs), antibodies, traditional medicines, toxin-antitoxin (TA) system. While these approaches offer innovative solutions addressing preserving efficacy therapies, challenges such as safety, cost-effectiveness, regulatory hurdles, large-scale implementation remain. examines potential limitations strategies, offering balanced perspective on their managing mitigating broader impact resistance.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 26, 2025
Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.
Language: Английский
Citations
0
Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: April 1, 2025
Language: Английский
Citations
0