Critical Review on Anti-Obesity Effects of Anthocyanins Through PI3K/Akt Signaling Pathways

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1126 - 1126

Published: March 24, 2025

Obesity is a global health crisis and one of the major reasons for rising prevalence metabolic disorders such as type 2 diabetes, cardiovascular diseases, certain cancers. There has been growing interest in search natural molecules with potential anti-obesity effects; among phytochemicals are anthocyanins, which flavonoid pigments present many fruits vegetables. Anthocyanins influence obesity via several signaling pathways. The PI3K/Akt pathway plays role focus on downstream targets GLUT4, FOXO, GSK3β, mTOR, play central regulation glucose metabolism, lipid storage, adipogenesis. critical factors oxidative stress inflammation also affect pathophysiology obesity. However, studies reviewed have limitations, including variations experimental models, bioavailability challenges, lack extensive clinical validation. While anthocyanin shows tremendous potential, challenges poor bioavailability, stability, regulatory matters must be overcome successful functional food inclusion anthocyanins. future anthocyanin-derived foods lies their ability to hurdles. Therefore, this review highlights molecular mechanisms through pathways explores how anthocyanins can modulate these address related disorders. It addresses some ways solve like while emphasizing possibilities anthocyanin-based management.

Language: Английский

Preliminary Evidence Suggests That a 12-Week Treatment with Tirzepatide Plus Low-Energy Ketogenic Therapy Is More Effective than Its Combination with a Low-Calorie Diet in Preserving Fat-Free Mass, Muscle Strength, and Resting Metabolic Rate in Patients with Obesity

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1216 - 1216

Published: March 30, 2025

Background: Tirzepatide (TZP), a unimolecular dual agonist targeting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, is promising weight loss agent in obesity. The preservation of metabolically active fat-free mass (FFM), muscle strength (MS), resting metabolic rate (RMR) essential for optimizing fat (FM) reduction. Although TZP typically combined with low-calorie diet (LCD), its impact on FFM uncertain, studies MS RMR are lacking. Evidence suggests that Low-Energy Ketogenic Therapy (LEKT) may reduce FM while preserving FFM, MS, RMR. Therefore, this study aimed to compare the effects an LEKT LCD, both TZP, body (BW), FM, patients Methods: We prospectively compared either LCD or 60 obesity (n = 30 per group) over 12 weeks. BW, were measured at baseline after Clinical parameters, assessment dietary compliance, side also evaluated. Results: At 12-week follow-up, groups showed significant BW reduction from (TZP+LEKT, p 0.0289; TZP+LCD, 0.0278), no intergroup difference (p 0.665). Similarly, decreased significantly cohorts < 0.001; 0.0185), TZP+LEKT group achieving greater 0.042). However, TZP+LCD exhibited declines 0.0284), 0.0341), 0.001), whereas we did not observe any changes 0.487), 0.691), 0.263) group. Intergroup direct comparisons confirmed experienced reductions 0.0388), 0.046), 0.019). Conclusions: Based findings these preliminary data, able support hypothesis seems be superior promoting

Language: Английский

Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions

Stresses, Journal Year: 2025, Volume and Issue: 5(2), P. 26 - 26

Published: April 4, 2025

Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.

Language: Английский