GFPrint™: A machine learning tool for transforming genetic data into clinical insights DOI Creative Commons

Guillermo Sanz-Martín,

Daniela Migliore,

Pablo Gómez del Campo

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0311370 - e0311370

Published: Nov. 27, 2024

The increasing availability of massive genetic sequencing data in the clinical setting has triggered need for appropriate tools to help fully exploit wealth information these possess. GFPrint™ is a proprietary streaming algorithm designed meet that need. By extracting most relevant functional features, transforms high-dimensional, noisy into an embedded representation, allowing unsupervised models create clusters can be re-mapped original information. Ultimately, this allows identification genes and pathways disease onset progression. been tested validated using two cancer genomic datasets publicly available. Analysis TCGA dataset identified panels whose mutations appear negatively influence survival non-metastatic colorectal (15 genes), epidermoid non-small cell lung (167 genes) pheochromocytoma (313 patients. Likewise, analysis Broad Institute 75 involved related extracellular matrix reorganization dictate worse prognosis breast accessible through secure web portal used any therapeutic area where profile patients influences evolution.

Language: Английский

Greylag goose optimization and multilayer perceptron for enhancing lung cancer classification DOI Creative Commons

El-Sayed M. El-kenawy,

Amel Ali Alhussan, Doaa Sami Khafaga

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 10, 2024

Lung cancer is an important global health problem, and it defined by abnormal growth of the cells in tissues lung, mostly leading to significant morbidity mortality. Its timely identification correct staging are very for proper therapy prognosis. Different computational methods have been used enhance precision lung classification, among which optimization algorithms such as Greylag Goose Optimization (GGO) employed. These purpose improving performance machine learning models that presented with a large amount complex data, selecting most features. As per data preparation one steps, contains operations scaling, normalization, handling gap factor ensure reasonable reliable input data. In this domain, use GGO includes refining feature selection, mainly focuses on enhancing classification accuracy compared other binary format algorithms, like bSC, bMVO, bPSO, bWOA, bGWO, bFOA. The efficiency bGGO algorithm choosing optimal features improved indicator possible application method field diagnosis. achieved highest MLP model at 98.4%. selection results were assessed using statistical analysis, utilized Wilcoxon signed-rank test ANOVA. also accompanied set graphical illustrations ensured adequacy adopted hybrid (GGO + MLP).

Language: Английский

Citations

9

Orthopedic disease classification based on breadth-first search algorithm DOI Creative Commons
Ahmed M. Elshewey, Ahmed M. Osman

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 8, 2024

Orthopedic diseases are widespread worldwide, impacting the body's musculoskeletal system, particularly those involving bones or hips. They have potential to cause discomfort and impair functionality. This paper aims address lack of supplementary diagnostics in orthopedics improve method diagnosing orthopedic diseases. The study uses binary breadth-first search (BBFS), particle swarm optimization (BPSO), grey wolf optimizer (BGWO), whale algorithm (BWAO) for feature selections, BBFS makes an average error 47.29% less than others. Then we apply six machine learning models, i.e., RF, SGD, NBC, DC, QDA, ET. dataset used contains 310 instances distinct features. Through experimentation, RF model led optimal outcomes during comparison remaining with accuracy 91.4%. parameters were optimized using four algorithms: BFS, PSO, WAO, GWO. To check how well works on dataset, this prediction evaluation metrics such as accuracy, sensitivity, specificity, F-score, AUC curve. results showed that BFS-RF can performance original classifier compared others 99.41% accuracy.

Language: Английский

Citations

6

Skin cancer classification based on an optimized convolutional neural network and multicriteria decision-making DOI Creative Commons
Neven Saleh,

Mohammed A. Hassan,

Ahmed M. Salaheldin

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 27, 2024

Abstract Skin cancer is a type of disease in which abnormal alterations skin characteristics can be detected. It treated if it detected early. Many artificial intelligence-based models have been developed for detection and classification. Considering the development numerous according to various scenarios selecting optimum model was rarely considered previous works. This study aimed develop classification select model. Convolutional neural networks (CNNs) form AlexNet, Inception V3, MobileNet V2, ResNet 50 were used feature extraction. Feature reduction carried out using two algorithms grey wolf optimizer (GWO) addition original features. images classified into four classes based on six machine learning (ML) classifiers. As result, 51 with different combinations CNN algorithms, without GWO ML To best results, multicriteria decision-making approach utilized rank alternatives by perimeter similarity (RAPS). Model training testing conducted International Imaging Collaboration (ISIC) 2017 dataset. Based nine evaluation metrics RAPS method, AlexNet algorithm classical yielded model, achieving accuracy 94.5%. work presents first benchmarking many models. not only reduces time spent but also improves accuracy. The method has proven its robustness problem

Language: Английский

Citations

5

Precise feature selection using suffix array algorithm of bioinformatics DOI

Aboozar Zandvakili,

Mohammad Masoud Javidi, N. Mansouri

et al.

International Journal of Machine Learning and Cybernetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0

Dynamic time-varying transfer function for cancer gene expression data feature selection problem DOI Creative Commons

Hao-Ming Song,

Yucai Wang, Jie-Sheng Wang

et al.

Journal Of Big Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 1, 2025

Language: Английский

Citations

0

Security-aware user authentication based on multimodal biometric data using dilated adaptive RNN with optimal weighted feature fusion DOI

Udhayakumar Selvaraj,

N. Janakiraman

Network Computation in Neural Systems, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41

Published: April 1, 2025

This work plans to develop a biometric authentication model by the combination of multi-modal inputs like voice, fingerprint, and iris provide high security. At first, spectrogram images, collected input were given Multi-scale Residual Attention Network (RAN) with Atrous Spatial Pyramid Pooling (ASPP) extract best values. These three features are then fed optimal weighted feature fusion, where weight optimization from is done via Enhanced Lichtenberg Algorithm (ELA). into decision-making stage, Dilated Adaptive Recurrent Neural utilized identify individuals, parameters optimized RNN using ELA improve recognition performance. The simulation findings achieved developed multimodal systems validated diverse algorithms over several efficacy metrics accuracy, precision, sensitivity, F1-score, etc. From result analysis, ELA-DARNN-based user system showed higher accuracy 96.01, other models such as 90% than SVM, CNN, CNN-AlexNet, Dil-ARNN be 87.94, 89.88, 93.25, 91.94. Therefore, outcomes explored that offered approach has attained elevated results also effectively supports reduction data theft.

Language: Английский

Citations

0

Identifying candidate biomarkers for detecting bronchogenic carcinoma stages using metaheuristic algorithms based on information fusion theory DOI Creative Commons

Bagher Khalvati,

Kaveh Kavousi, Amir Hosein Keyhanipour

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 29, 2025

Language: Английский

Citations

0

Feature Selection of Gene Expression Data Using a Modified Artificial Fish Swarm Algorithm With Population Variation DOI Creative Commons

Zong-Zheng Li,

Fang-Ling Wang, Feng Qin

et al.

IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 72688 - 72706

Published: Jan. 1, 2024

Microarray data is of great significance for cancer identification at the gene level. In microarray dataset, only a small number characteristic genomes have significant classification and rates cancer. How to extract genes from large classic NP-hard problem. This paper proposes practical hybrid approach implement feature selection expression by combining F-score algorithm an improved artificial fish swarm with population variation (FSA-PV). Firstly, eliminates useless redundant features in set. Then, FSA-PV discussed obtain ability jump out local optimum while retaining excellent subset as much possible, adaptive step visual are used adjust search space move range different environments improve optimization global abilities. addition, naive Bayesian classifier test accuracy subsets. Eight classical datasets verify performance proposed mechanism experiment part. The results reveal that using superior other algorithms Breast more than 90% 8 cases. It further indicates robustness feasibility process.

Language: Английский

Citations

3

An Improved Expeditious Meta-Heuristic Clustering Method for Classifying Student Psychological Issues with Homogeneous Characteristics DOI Creative Commons

Muhammad Suhail Shaikh,

Xiaoqing Dong, Gengzhong Zheng

et al.

Mathematics, Journal Year: 2024, Volume and Issue: 12(11), P. 1620 - 1620

Published: May 22, 2024

Nowadays, cluster analyses are widely used in mental health research to categorize student stress levels. However, conventional clustering methods experience challenges with large datasets and complex issues, such as converging local optima sensitivity initial random states. To address these limitations, this work introduces an Improved Grey Wolf Clustering Algorithm (iGWCA). This improved approach aims adjust the convergence rate mitigate risk of being trapped optima. The iGWCA algorithm provides a balanced technique for exploration exploitation phases, alongside search mechanism around optimal solution. assess its efficiency, proposed is verified on two different datasets. dataset-I comprises 1100 individuals obtained from Kaggle database, while dataset-II based 824 Mendeley database. results demonstrate competence classifying outperforms other terms lower intra-cluster distances, obtaining reduction 1.48% compared Optimization (GWO), 8.69% Mayfly (MOA), 8.45% Firefly (FFO), 2.45% Particle Swarm (PSO), 3.65%, Hybrid Sine Cosine Cuckoo (HSCCS), 8.20%, Genetic (FAGA) 8.68% Gravitational Search (GSA). demonstrates effectiveness minimizing making it better choice classification. contributes advancement understanding managing well-being within academic communities by providing robust tool level

Language: Английский

Citations

3

A hybrid bat and grey wolf optimizer for gene selection in cancer classification DOI
Dina Tbaishat, Mohammad Tubishat, Sharif Naser Makhadmeh

et al.

Knowledge and Information Systems, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Language: Английский

Citations

3