COVID-19-Associated Pulmonary Mucormycosis DOI Creative Commons
Vidya Krishna, N.K. Bansal, Jaymin B. Morjaria

et al.

Journal of Fungi, Journal Year: 2022, Volume and Issue: 8(7), P. 711 - 711

Published: July 5, 2022

COVID-19-associated mucormycosis (CAM) emerged as an epidemic in certain parts of the world amidst global COVID-19 pandemic. While rhino-orbital was well reported during pandemic, absence routine diagnostic facilities including lower airway sampling, pulmonary probably under-recognized. In this review, we have focused on epidemiology and management (CAPM). CAPM is a deadly disease mortality can be high 80% early clinical suspicion treatment. histopathological examination tissue for angio-invasion cultures remained gold standard diagnosis, there increasing interest molecular serological methods to facilitate diagnosis critically ill patients often, immune-suppressed hosts who cannot readily undergo invasive sampling. Combined medical surgical treatment offers more promise than standalone therapy. Maintaining adequate glycemic control prudent use steroids which double-edged sword are key preventative measures. We would like emphasize urgent need development validation reliable biomarkers diagnostics diagnosis.

Language: Английский

Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India DOI Creative Commons
Valliappan Muthu, Ritesh Agarwal, Shivaprakash M. Rudramurthy

et al.

Emerging infectious diseases, Journal Year: 2023, Volume and Issue: 29(1), P. 8 - 19

Published: Jan. 1, 2023

Abstract We performed a case–control study across 25 hospitals in India for the period of January–June 2021 to evaluate reasons an COVID-19–associated mucormycosis (CAM) outbreak. investigated whether COVID-19 treatment practices (glucocorticoids, zinc, tocilizumab, and others) were associated with CAM. included 1,733 cases CAM 3,911 age-matched controls. found cumulative glucocorticoid dose (odds ratio [OR] 1.006, 95% CI 1.004–1.007) zinc supplementation (OR 2.76, 2.24–3.40), along elevated C-reactive protein 1.004, 1.002–1.006), host factors (renal transplantation [OR 7.58, 3.31–17.40], diabetes mellitus 6.72, 5.45–8.28], diabetic ketoacidosis during 4.41, 2.03–9.60]), rural residence 2.88, 2.12–3.79), significantly Mortality rate at 12 weeks was 32.2% (473/1,471). emphasize judicious use therapies optimal glycemic control prevent

Language: Английский

Citations

47
The changing epidemiology of fungal infections DOI Creative Commons
Cornelia Lass‐Flörl, Stephan Steixner

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 94, P. 101215 - 101215

Published: Oct. 5, 2023

Invasive fungal diseases are common complications in critically ill patients and those with significant underlying imbalanced immune systems. Fungal co-, and/or super-infections emerging have become a rising concern within the last few years. In Europe, cases of candidiasis aspergillosis dominate, followed by mucormycosis India. Epidemiological studies show an increasing trend incidence all three entities. Parallel to this, shift pathogens is observed. More non-albicans Candida infections cryptic species on rise; may cover intrinsic resistance azoles other antifungal drugs. The recent COVID-19 pandemic led significantly invasive among hospitalized patients.

Language: Английский

Citations

43
COVID-19-Associated Pulmonary Mucormycosis DOI Creative Commons
Vidya Krishna, N.K. Bansal, Jaymin B. Morjaria

et al.

Journal of Fungi, Journal Year: 2022, Volume and Issue: 8(7), P. 711 - 711

Published: July 5, 2022

COVID-19-associated mucormycosis (CAM) emerged as an epidemic in certain parts of the world amidst global COVID-19 pandemic. While rhino-orbital was well reported during pandemic, absence routine diagnostic facilities including lower airway sampling, pulmonary probably under-recognized. In this review, we have focused on epidemiology and management (CAPM). CAPM is a deadly disease mortality can be high 80% early clinical suspicion treatment. histopathological examination tissue for angio-invasion cultures remained gold standard diagnosis, there increasing interest molecular serological methods to facilitate diagnosis critically ill patients often, immune-suppressed hosts who cannot readily undergo invasive sampling. Combined medical surgical treatment offers more promise than standalone therapy. Maintaining adequate glycemic control prudent use steroids which double-edged sword are key preventative measures. We would like emphasize urgent need development validation reliable biomarkers diagnostics diagnosis.

Language: Английский

Citations

20