Introduction about Global infectious disease and use of nanotechnology DOI Open Access

Ankita Y. Gawai,

R.L. Bakal, Pooja R. Hatwar

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(12), P. 181 - 190

Published: Dec. 15, 2024

Infectious diseases, including COVID-19, malaria, tuberculosis, and sexually transmitted diseases (STDs), pose significant threats to global health. Nanotechnology has emerged as a promising tool in the diagnosis, treatment, prevention of these diseases. This review highlights applications nanotechnology combating infectious Nanoparticles, such metallic nanoparticles, liposomes, quantum dots, have been employed detection treatment Nanotechnology-based drug delivery systems improved efficacy reduced toxicity antiviral antibacterial drugs. Additionally, enabled development point-of-care diagnostics vaccines for provides an overview current state disease management its potential revolutionize field. By leveraging unique properties can provide innovative solutions ultimately improving health outcomes. Keywords: Nanotechnology, Malaria, Tuberculosis, HIV/AIDS

Language: Английский

Revolutionizing Nanovaccines: A New Era of Immunization DOI Creative Commons
Mohammed A. Saleh,

Ahmed El-Moghazy,

Adel Helmy Elgohary

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 27, 2025

Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.

Language: Английский

Citations

0
Spectral and Cytotoxicity Studies of Hybrid Silver Nanoparticles in Human Lymphocytes DOI
Uroš Ralević, Andreja Leskovac, Sandra Petrović

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Therapeutic Effect of Cisplatin-Loaded Polymeric Nanoparticles and Nimotuzumab Combination in Human Glioblastoma Cells DOI Creative Commons
Elif Kağa, Serhat Korkmaz, Sadık Kağa

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Objective This study evaluated the combined therapeutic effects of cisplatin-loaded PEG-PLGA nanoparticles (CIS-PEG-PLGA) and nimotuzumab (NIMO) on glioblastoma (GBM) cells, focusing their antiproliferative, apoptotic, cell cycle-modulatory effects. Materials Methods were synthesized using a double-emulsion solvent evaporation method, achieving mean particle size ~ 450 nm. Cisplatin release kinetics, proliferation, apoptosis, cycle progression assessed in U87 cells. The treatments included free cisplatin (CIS), CIS-PEG-PLGA, NIMO, combinations. Experiments performed triplicate, statistical analyses ANOVA test. Results CIS-PEG-PLGA exhibited sustained release, with 50% released within 8 h nearly 100% 72 h. combination + NIMO reduced proliferation by 90%, significantly surpassing that CIS (50%) (70%). Apoptosis rates highest group (27.52%), followed (18.59%) (25.95%). Cell analysis revealed significant G2 phase arrest (30.12%) treatment group, highlighting its superior modulatory progression. Conclusion demonstrated synergistic enhancing outcomes. approach represents promising advancement therapy integrating nanotechnology immunotherapy to overcome conventional limitations. Further, vivo studies are warranted validate these findings explore clinical applications.

Language: Английский

Citations

0
Drug resistance and possible therapeutic options against influenza A virus infection over past years DOI

Muhammad Asif Raza,

Muhammad Awais Ashraf

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(12)

Published: Nov. 5, 2024

Language: Английский

Citations

2
Introduction about Global infectious disease and use of nanotechnology DOI Open Access

Ankita Y. Gawai,

R.L. Bakal, Pooja R. Hatwar

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(12), P. 181 - 190

Published: Dec. 15, 2024

Infectious diseases, including COVID-19, malaria, tuberculosis, and sexually transmitted diseases (STDs), pose significant threats to global health. Nanotechnology has emerged as a promising tool in the diagnosis, treatment, prevention of these diseases. This review highlights applications nanotechnology combating infectious Nanoparticles, such metallic nanoparticles, liposomes, quantum dots, have been employed detection treatment Nanotechnology-based drug delivery systems improved efficacy reduced toxicity antiviral antibacterial drugs. Additionally, enabled development point-of-care diagnostics vaccines for provides an overview current state disease management its potential revolutionize field. By leveraging unique properties can provide innovative solutions ultimately improving health outcomes. Keywords: Nanotechnology, Malaria, Tuberculosis, HIV/AIDS

Language: Английский

Citations

0