Hydrogen Sulfide and Gut Microbiota: Their Synergistic Role in Modulating Sirtuin Activity and Potential Therapeutic Implications for Neurodegenerative Diseases

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1480 - 1480

Published: Nov. 4, 2024

The intricate relationship between hydrogen sulfide (H2S), gut microbiota, and sirtuins (SIRTs) can be seen as a paradigm axis in maintaining cellular homeostasis, modulating oxidative stress, promoting mitochondrial health, which together play pivotal role aging neurodegenerative diseases. H2S, gasotransmitter synthesized endogenously by specific acts potent modulator of function protecting against damage. Through sulfate-reducing bacteria, microbiota influences systemic H2S levels, creating link health metabolic processes. Dysbiosis, or an imbalance microbial populations, alter production, impair function, increase heighten inflammation, all contributing factors diseases such Alzheimer’s Parkinson’s. Sirtuins, particularly SIRT1 SIRT3, are NAD+-dependent deacetylases that regulate biogenesis, antioxidant defense, inflammation. enhances sirtuin activity through post-translational modifications, sulfhydration, activate pathways essential for mitigating damage, reducing longevity. SIRT1, example, deacetylates NF-κB, pro-inflammatory cytokine expression, while SIRT3 modulates key enzymes to improve energy metabolism detoxify reactive oxygen species (ROS). This synergy is profoundly influenced the levels and, turn, impacts activation. microbiota–H2S–sirtuin also regulating neuroinflammation, plays central pathogenesis Pharmacological interventions, including donors sirtuin-activating compounds (STACs), promise these synergistically, providing novel therapeutic approach conditions. suggests diversity optimal have far-reaching effects on brain health.

Language: Английский

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Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3131 - 3131

Published: March 28, 2025

Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function neurotransmitter release neuronal circuits. By synthesizing findings from animal cellular models, we investigate impacts of enzymatic production exogenous on excitatory currents, long-term potentiation, intracellular calcium signaling. Data suggest that interacts directly with subunits, altering excitability. Simultaneously, promotes neurotransmitters such glutamate GABA, shaping dynamics plasticity. Furthermore, reports indicate disruptions metabolism contribute to cognitive impairments neurodegenerative disorders, underscoring potential therapeutic value targeting H2S-mediated Although precise mechanisms H2S-induced changes strength remain elusive, growing body positions significant regulator formation processes. calls for more rigorous exploration into underpinnings paving way novel pharmacological interventions dysfunction.

Language: Английский

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Plant-based antioxidant peptides: impact on oxidative stress and gut microbiota

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: April 12, 2025

Plant-based peptides can be obtained from natural and climate-friendly sources. These show various bioactivities including antioxidant activity. Oxidative stress has an impact on the gut microbiota causing inflammation, insulin resistance, osteoporosis, cancer, several chronic diseases like type 2 diabetes, arthritis, hypertension, atherosclerosis. Therefore, may significantly affect oxidative as a potential alternative to conventional medication. The production of plant-based protein sources through innovative approaches provide promising strategies improve microbiota. Recent studies in (PBAP) focus their advanced identification characterization techniques, structure-activity relationship, improvement extraction purification, cellular molecular mechanisms, specific health applications preventing managing conditions with microbiota, commercial nutraceuticals. Short-chain fatty acids reactive sulfur species are gut-derived metabolites that metabolic function by modulating immune system. This review highlights influence food oxidants PBAP-induced modulation Moreover, PBAP challenges application will discussed.

Language: Английский

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Reconnecting the roots of hydrogen sulfide (H2S) with medicinal chemistry: Lessons accomplished and challenges so far

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108569 - 108569

Published: May 8, 2025

Language: Английский

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