4D Printed shape memory polymers in focused ultrasound fields

Additive manufacturing, Journal Year: 2024, Volume and Issue: unknown, P. 104465 - 104465

Published: Oct. 1, 2024

Language: Английский

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In Vitro Sonodynamic Therapy Using a High Throughput 3D Glioblastoma Spheroid Model with 5‐ALA and TMZ Sonosensitizers

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Sonodynamic therapy (SDT) administered using low‐intensity pulsed ultrasound and sonosensitizers is an emerging, minimally invasive, targeted deep‐tissue for solid tumors such as glioblastoma multiforme (GBM). Initial clinical trials show promising outcomes SDT treatments of GBM. A crucial aspect the sonosensitizer that interacts with ultrasound, facilitating energy transfer to tumor, thus inducing therapeutic efficacy. Current in vitro methods determining efficacies are time‐consuming expensive. novel high‐throughput magnetically printed 3D GBM model used overcome this challenge. The hypothesis use two sonosensitizers, one a chemotherapeutic drug, enhances efficacy through their additive chemical interactions. evaluate effectiveness molecules, 5‐aminolevulinic acid (5‐ALA) theU.S. Food Drug Administration (FDA)‐approved drug Temozolomide (TMZ). It confirmed implement models combinations feasible and, first time, combined effect both sensitizers, 5‐ALA TMZ, superior preventing spheroid growth than employing each molecule separately. This finding relevant future treatment SDT.

Language: Английский

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Recent advances and future directions in sonodynamic therapy for cancer treatment

BME Frontiers, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Deep-tissue solid cancer treatment has a poor prognosis, resulting in very low 5-year patient survival rate. The primary challenges facing tumor therapies are accessibility, incomplete surgical removal of tissue, the resistance hypoxic and heterogeneous microenvironment to chemotherapy radiation, suffering caused by off-target toxicities. Here, sonodynamic therapy (SDT) is an evolving therapeutic approach that uses low-intensity ultrasound target deep-tissue tumors. ability deliver energy safely precisely into small (>10 cm) volumes makes SDT more effective than conventional photodynamic therapy. While currently phase 1/2 clinical trials for glioblastoma multiforme, its use other treatments, such as breast, pancreatic, liver, prostate cancer, still preclinical stage, with further investigation required improve efficacy. This review, therefore, focuses on recent advances treatments. We describe interaction between sonosensitizer molecules associated transfer mechanism malignant cells, which plays central role SDT-mediated cell death. Different sensitizers used various treatments listed, critical parameters reviewed. also discuss approaches efficacies these sonosensitizers, 3-dimensional spheroid vitro investigations, ultrasound-controlled CAR-T SDT-based multimodal therapy, machine learning optimization, could facilitate translation SDT.

Language: Английский

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Mid-Intensity 30.5 GHz Continuous Wave Exposure of Glioblastoma Organoids

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

In this chapter, we delve into the therapeutic potential of 30.5 GHz millimeter waves on 3D glioblastoma organoids. We specifically investigated mild thermal radiation effects in context new emerging focused energy delivery and bioelectromagnetic approaches. Our in-house developed exposure system, coupled with a rigorous dosimetry protocol extensive multi-physics modeling, supported biological endpoint evaluation terms transcriptional profiling, cell morphological changes, phenotypic characterization. Crucially, induced effect was minimal, aligning closely our simulation models indicating precise control delivery. Notably, 0.1 W power level enhanced efficacy Temozolomide, significantly increasing apoptosis while not affecting differentiation status organoid cells. This combination suggests avenue for treatment, leveraging wave-induced mechanisms that warrant further investigation. findings underscore promise minimally invasive technique, offering glimpse future therapies.

Language: Английский

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Treatment-induced ripple effect: a systematic review exploring the abscopal phenomenon in Glioblastoma multiforme

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

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