Advances in CAR NK Cell Therapy for Targeting and Eradicating Circulating Tumor Cells: Challenges and Solutions for Aging Patients Mini Review DOI Creative Commons
Dmitri Toren, Eugen Ursu, Bogdan Ghilic-Micu

et al.

Ageing & Longevity, Journal Year: 2024, Volume and Issue: 4 2024, P. 157 - 173

Published: Nov. 11, 2024

Chimeric Antigen Receptor (CAR) Natural Killer (NK) cells represent a promising advancement in cancer immunotherapy, particularly for targeting circulating tumor (CTCs) and preventing metastasis. This review examines the latest developments CAR NK cell therapy, including diverse sources, genetic engineering techniques, dual mechanisms of action. Targeting CTCs with shows significant potential aggressive cancers like triple-negative breast (TNBC) pancreatic cancer. The impact aging on function, especially regarding cytotoxicity, cytokine secretion, persistence, poses challenges elderly patients, but strategies such as interleukin-15 metabolic interventions offer solutions. also addresses current limitations, poor persistence immunosuppressive microenvironments low solid infiltration, while proposing combination therapies to enhance effectiveness. Although still earlier clinical stages compared T cells, cells’ safety profile MHC-independent recognition make them versatile therapeutic option. Future directions include optimizing improving developing age-adapted patients. _________________________________________________________________________________________ Keywords: Circulating (CTCs), Cell Therapy, Aging

Language: Английский

Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors DOI Creative Commons
Zhiguang Chen, Liang Sang,

Zhai Qixi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661

Published: March 1, 2025

Language: Английский

Citations

0
Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening DOI Creative Commons

Chris Payne,

Paul Cressey,

Anisia Talianu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e39972 - e39972

Published: Nov. 1, 2024

Highlights•Focused ultrasound in conjunction with circulating microbubbles is the only technology that can bypass blood-brain barrier and enhance delivery of chemotherapeutics to brain a targeted non-invasive manner•Liposomes are versatile drug carriers be reliably delivered using clinically relevant therapeutic ultrasound•Imageable liposomes tracked MRI near infrared fluorescence imaging, confirming their vivo biodistribution•Passive acoustic measurements correlate liposome vivo, providing scalable safe method for therapy confirmation clinicAbstractFocused ultrasound-mediated opening offers great opportunity deliver therapeutics into hard-to-treat tumors such as glioblastoma multiforme or diffuse midline glioma. However, potential technique offer time window efficient nanomedicine has not been thoroughly studied. Non-invasive large drug-loaded nanocarriers, liposomes, could personalized treatment pathologies. Additionally, it essential monitor safety efficacy treatments, tracking real-time through quantitative medical imaging.In this study, were modified have an contrast agent (i.e., Gd) both lipid membrane core, while dye CW800) was coupled lipids introduced bilayer bimodal detection verification. Targeted 110nm-in-diameter quantified 9.4-T imaging. The spatiotemporal distribution assessed up 4 hours post T1 weighted MRI. In signal co-localized NIRF from excised brains ex vivo. Passive during treatments revealed correlation between contrast, metric assessing clinical real-time. conclusion, exposure trackable nanoparticles brain, enabling monitoring verification.Graphical abstract

Language: Английский

Citations

2
Multidisciplinary management strategies for recurrent brain metastasis after prior radiotherapy: An overview DOI Creative Commons
Rupesh Kotecha, Alonso La Rosa, Paul D. Brown

et al.

Neuro-Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

As cancer patients with intracranial metastatic disease experience increasingly prolonged survival, the diagnosis and management of recurrent brain metastasis pose significant challenges in clinical practice. Prior to deciding upon a strategy, it is necessary ascertain whether have recurrent/progressive vs adverse radiation effect, classify recurrence as local or distant brain, evaluate extent (size, number location lesions, velocity), status extracranial disease, enumerate interval from last intracranially directed intervention recurrence. A spectrum salvage treatment options includes surgery (resection laser interstitial thermal therapy [LITT]) without adjuvant radiotherapy forms external beam radiotherapy, intraoperative brachytherapy. Nonoperative treatments also range single fraction fractionated stereotactic radiosurgery (SRS/FSRS) whole (WBRT). Optimal integration systemic therapies, preferably central nervous system (CNS) activity, may require reinterrogation tissue identify actionable molecular alterations specific progressive disease. Ultimately, selection appropriate approach necessitates sophisticated understanding patient, tumor, prior treatment-related factors often multimodal; hence, interdisciplinary evaluation for such indispensable.

Language: Английский

Citations

2
Overcoming Treatment Resistance in Medulloblastoma: Underlying Mechanisms and Potential Strategies DOI Open Access
Hasan Slika,

Aanya Shahani,

Riddhpreet Kaur Wahi

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2249 - 2249

Published: June 18, 2024

Medulloblastoma is the most frequently encountered malignant brain tumor in pediatric population. The standard of care currently consists surgical resection, craniospinal irradiation, and multi-agent chemotherapy. However, despite this combination multiple aggressive modalities, recurrence disease remains a substantial concern, treatment resistance rising issue. development results from interplay myriad anatomical properties, cellular processes, molecular pathways, genetic epigenetic alterations. In fact, several efforts have been directed towards domain characterizing major contributors to resistance. Herein, review highlights different mechanisms that drive relapse are implicated occurrence discusses them context latest molecular-based classification medulloblastoma. These include impermeability blood-brain barrier drugs, overactivation specific resistant multipotent nature cancer stem cells, intratumoral intertumoral heterogeneity, metabolic plasticity. Subsequently, we build on explore potential strategies targeted agents can abrogate these mechanisms, undermine resistance, augment medulloblastoma’s response therapeutic modalities.

Language: Английский

Citations

1
Sonodynamic therapy for adult-type diffuse gliomas: past, present, and future DOI

Sydney E Scanlon,

Regan M. Shanahan, Othman Bin-Alamer

et al.

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: 169(3), P. 507 - 516

Published: July 23, 2024

Language: Английский

Citations

1
A Scoping Review of Focused Ultrasound Enhanced Drug Delivery for Across the Blood–Brain Barrier for Brain Tumors DOI

Christopher M. Young,

Ariel Viña-González,

Rodrigo Salmeron de Toledo Aguiar

et al.

Operative Neurosurgery, Journal Year: 2024, Volume and Issue: 27(5), P. 523 - 532

Published: May 8, 2024

BACKGROUND AND OBJECTIVES: Previous mechanisms of opening the blood–brain barrier (BBB) created a hypertonic environment. Focused ultrasound (FUS) has recently been introduced as means controlled BBB opening. Here, we performed scoping review to assess advances in drug delivery across for treatment brain tumors identify and literature gaps. METHODS: A current was conducted through MEDLINE search inclusive articles on FUS, BBB, tumor barrier, including human, modeling, animal studies written English. Using Rayyan platform, 2 reviewers (J.P C.Y) identified 967 publications. 224 were chosen after title screen. Ultimately 98 reviewed. The designed address following questions: (1) What FUS technology improvements have made augment tumors? (2) occurred ensure better uptake target tissue RESULTS: Microbubbles (MB) with are used (BBBO) cavitation increase its permeability. Drug into central nervous system can be combined MB enhance transport therapeutic agents resulting suppression growth prolonging survival rate, well reducing systemic toxicity degradation rate. There is accumulating evidence demonstrating that BBBO FUS-MB improves concentrations provides impact rates, compared drug-only treatments. CONCLUSION: role BBBO. Identified gaps include microenvironment extracellular space, improved understanding control delivery, further work ideal pharmacologics clinical use.

Language: Английский

Citations

0
Advances in CAR NK Cell Therapy for Targeting and Eradicating Circulating Tumor Cells: Challenges and Solutions for Aging Patients Mini Review DOI Creative Commons
Dmitri Toren, Eugen Ursu, Bogdan Ghilic-Micu

et al.

Ageing & Longevity, Journal Year: 2024, Volume and Issue: 4 2024, P. 157 - 173

Published: Nov. 11, 2024

Chimeric Antigen Receptor (CAR) Natural Killer (NK) cells represent a promising advancement in cancer immunotherapy, particularly for targeting circulating tumor (CTCs) and preventing metastasis. This review examines the latest developments CAR NK cell therapy, including diverse sources, genetic engineering techniques, dual mechanisms of action. Targeting CTCs with shows significant potential aggressive cancers like triple-negative breast (TNBC) pancreatic cancer. The impact aging on function, especially regarding cytotoxicity, cytokine secretion, persistence, poses challenges elderly patients, but strategies such as interleukin-15 metabolic interventions offer solutions. also addresses current limitations, poor persistence immunosuppressive microenvironments low solid infiltration, while proposing combination therapies to enhance effectiveness. Although still earlier clinical stages compared T cells, cells’ safety profile MHC-independent recognition make them versatile therapeutic option. Future directions include optimizing improving developing age-adapted patients. _________________________________________________________________________________________ Keywords: Circulating (CTCs), Cell Therapy, Aging

Language: Английский

Citations

0