Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders DOI
Heena Khan, Chanchal Tiwari,

Amarjot Kaur Grewal

et al.

Inflammopharmacology, Journal Year: 2022, Volume and Issue: 30(6), P. 2051 - 2061

Published: Oct. 22, 2022

Language: Английский

Therapeutic Insights on Ferroptosis in Parkinson's disease DOI

Komal Thapa,

Heena Khan, Neha Kanojia

et al.

European Journal of Pharmacology, Journal Year: 2022, Volume and Issue: 930, P. 175133 - 175133

Published: July 2, 2022

Language: Английский

Citations

56
α-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective DOI
Heena Khan, Thakur Gurjeet Singh, Randhir Singh

et al.

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(7), P. 1853 - 1864

Published: April 21, 2022

Language: Английский

Citations

37
Targeting ferroptosis in ischemia/reperfusion renal injury DOI

Komal Thapa,

Thakur Gurjeet Singh,

Amarjot Kaur

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2022, Volume and Issue: 395(11), P. 1331 - 1341

Published: Aug. 3, 2022

Language: Английский

Citations

35
Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches DOI

Nirbhay Kumar Prabhakar,

Heena Khan,

Amarjot Kaur Grewal

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 108, P. 108902 - 108902

Published: May 31, 2022

Language: Английский

Citations

30
Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders DOI

Vivek Rihal,

Heena Khan,

Amarjot Kaur

et al.

Psychiatry Research, Journal Year: 2022, Volume and Issue: 317, P. 114782 - 114782

Published: Aug. 14, 2022

Language: Английский

Citations

27
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration DOI

Nilima Khakha,

Heena Khan,

Amarjot Kaur

et al.

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1152 - 1165

Published: Sept. 9, 2023

Language: Английский

Citations

17
Emerging Targets for Modulation of Immune Response and Inflammation in Stroke DOI

Komal Thapa,

Shivam Kumar, Heena Khan

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(6), P. 1663 - 1690

Published: Feb. 10, 2023

Language: Английский

Citations

16
Caspase-mediated regulation of the distinct signaling pathways and mechanisms in neuronal survival DOI
Heena Khan,

Annu Bangar,

Amarjot Kaur Grewal

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 110, P. 108951 - 108951

Published: June 16, 2022

Language: Английский

Citations

23
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment DOI

Chahat Garg,

Heena Khan,

Amarjot Kaur

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 179, P. 106194 - 106194

Published: March 29, 2022

Language: Английский

Citations

22
Calpain signaling: from biology to therapeutic opportunities in neurodegenerative disorders DOI Creative Commons
Elsayed Metwally, Hatim A. Al-Abbadi, Tarique Hussain

et al.

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 5, 2023

Neurodegenerative disorders represent a major and growing healthcare challenge globally. Among the numerous molecular pathways implicated in their pathogenesis, calpain signaling has emerged as crucial player neuronal dysfunction cell death. Calpain is family of calcium-dependent cysteine proteases that involved many biological processes, such signal transduction, cytoskeleton remodeling, protein turnover. Dysregulation activation activity been associated with several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s diseases. Understanding intricate structure calpains for unraveling roles cellular physiology implications pathology. In addition, identification diverse abnormalities both humans other animal models deficiencies highlights significant progress made understanding biology. this comprehensive review, we delve into recent attributed to provide an overview mechanisms govern during progression The possibility utilizing inhibition potential therapeutic approach treating dysfunctions would be area interest future research.

Language: Английский

Citations

13