Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: July 24, 2024
Spinal
cord
injury
(SCI)
denotes
damage
to
both
the
structure
and
function
of
spinal
cord,
primarily
manifesting
as
sensory
motor
deficits
caused
by
disruptions
in
neural
transmission
pathways,
potentially
culminating
irreversible
paralysis.
Its
pathophysiological
processes
are
complex,
with
numerous
molecules
signaling
pathways
intricately
involved.
Notably,
pronounced
upregulation
Wnt
pathway
post-SCI
holds
promise
for
regeneration
repair.
Activation
plays
a
crucial
role
neuronal
differentiation,
axonal
regeneration,
local
neuroinflammatory
responses,
cell
apoptosis,
highlighting
its
potential
therapeutic
target
treating
SCI.
However,
excessive
activation
can
also
lead
negative
effects,
need
further
investigation
into
applicability
significance
This
paper
provides
an
overview
latest
research
advancements
SCI,
summarizing
recent
progress
treatment
strategies
associated
analyzing
their
advantages
disadvantages.
Additionally,
we
offer
insights
clinical
application
along
prospective
avenues
future
direction.
Frontiers in Cellular Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: April 18, 2022
Spinal
cord
injury
(SCI)
not
only
affects
the
quality
of
life
patients
but
also
poses
a
heavy
burden
on
their
families.
Therefore,
it
is
essential
to
prevent
occurrence
SCI;
for
unpreventable
SCI,
critical
develop
effective
treatments.
In
recent
years,
various
major
breakthroughs
have
been
made
in
cell
therapy
protect
and
regenerate
damaged
spinal
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: March 3, 2023
Extracellular
vesicles
(EVs)
including
exosomes
are
vesicular
with
phospholipid
bilayer
implicated
in
many
cellular
interactions
and
have
the
ability
to
transfer
multiple
types
of
cargo
cells.
It
has
been
found
that
EVs
can
package
various
molecules
proteins
nucleic
acids
(DNA,
mRNA,
noncoding
RNA).
The
discovery
as
carriers
forms
RNA,
such
microRNAs
(miRNA)
long
RNAs
(lncRNA),
raised
great
interest
field
drug
delivery.
Despite
underlying
mechanisms
neuropathic
pain
being
unclear,
it
shown
uncontrolled
glial
cell
activation
neuroinflammation
response
noxious
stimulation
important
emergence
maintenance
pain.
Many
studies
demonstrated
a
role
for
pathogenesis
may
offer
possibilities
potential
treatment.
In
this
article,
origins
clinical
application
mechanism
development
briefly
introduced.
Furthermore,
we
demonstrate
therapeutic
roles
involve
regulation
neuroinflammation.
Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: July 24, 2024
Spinal
cord
injury
(SCI)
denotes
damage
to
both
the
structure
and
function
of
spinal
cord,
primarily
manifesting
as
sensory
motor
deficits
caused
by
disruptions
in
neural
transmission
pathways,
potentially
culminating
irreversible
paralysis.
Its
pathophysiological
processes
are
complex,
with
numerous
molecules
signaling
pathways
intricately
involved.
Notably,
pronounced
upregulation
Wnt
pathway
post-SCI
holds
promise
for
regeneration
repair.
Activation
plays
a
crucial
role
neuronal
differentiation,
axonal
regeneration,
local
neuroinflammatory
responses,
cell
apoptosis,
highlighting
its
potential
therapeutic
target
treating
SCI.
However,
excessive
activation
can
also
lead
negative
effects,
need
further
investigation
into
applicability
significance
This
paper
provides
an
overview
latest
research
advancements
SCI,
summarizing
recent
progress
treatment
strategies
associated
analyzing
their
advantages
disadvantages.
Additionally,
we
offer
insights
clinical
application
along
prospective
avenues
future
direction.
