Hyaluronic Acid-Based Nanoparticles Loaded with Rutin as Vasculo-Protective Tools against Anthracycline-Induced Endothelial Damages DOI Creative Commons
Carla Serri, Vincenzo Quagliariello, Iriczalli Cruz‐Maya

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 985 - 985

Published: July 25, 2024

Anthracycline-based therapies exert endothelial damages through peroxidation and the production of proinflammatory cytokines, resulting in a high risk cardiovascular complications cancer patients. Hyaluronic acid-based hybrid nanoparticles (LicpHA) are effective pharmacological tools that can target cells deliver drugs or nutraceuticals. This study aimed to prepared characterized novel LicpHA loaded with Rutin (LicpHA Rutin), flavonoid antioxidant anti-inflammatory properties, protect against epirubicin-mediated damages. was using phosphatidylcholine, cholesterol, poloxamers, hyaluronic acid by modified nanoprecipitation technique. The chemical-physical characterization carried out (size, zeta potential, morphology, stability, thermal analysis, encapsulation efficiency). Cytotoxicity studies were performed human exposed epirubicin alone combination Free-Rutin Rutin. Anti-inflammatory intracellular quantification NLRP-3, MyD-88, IL-1β, IL-6, IL17-α, TNF-α, IL-10, IL-4 selective ELISA methods. Morphological via TEM image analysis highlighted heterogeneous population particles non-spherical shapes (circularity equal 0.78 ± 0.14), particle size slightly affected entrapment (the mean diameter varied from 179 4 nm 209 nm). Thermal potential analyses confirmed influence on properties Rutin, mainly indicated decrease surface negative charge (from −35 1 mV −30 0.5 mV). Cellular demonstrated significantly reduced cell death inflammation when compared alone. levels NLRP3, Myd-88, cytokines lower + Rutin-exposed groups (p < 0.001). exerts significant vasculo-protective during exposure anthracyclines. overall picture this pushes towards preclinical clinical models anthracycline-induced vascular

Language: Английский

Prepubertal Repeated Berberine Supplementation Enhances Cerebrocerebellar Functions by Modulating Neurochemical and Behavioural Changes in Wistar Rats DOI
Solomon E. Owumi, Joseph Chimezie, Moses T. Otunla

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(3)

Published: July 23, 2024

Language: Английский

Citations

3
GV‐971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities DOI Creative Commons
Xinying Yang,

Zhongheng Zhangyi,

Aisong Yu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Growing evidence suggests that an imbalanced gut microbiota composition plays a crucial role in the development of neuromyelitis optica spectrum disorders (NMOSD), inflammatory demyelinating disease primarily affecting optic nerves and central nervous system (CNS). In light this, we explored potential therapeutic benefits GV-971 NMOSD. is drug used for treating mild-to-moderate Alzheimer's disease, which targets gut-brain axis reduces neuroinflammation.

Language: Английский

Citations

2
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide DOI Creative Commons
Solomon E. Owumi, Joseph Chimezie,

Praise Dyap Emmanuel

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 25, 2024

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15), subsequently administered DEN continuously another 7 days, (days:15–21). Behavioural tests (OFT- using open field test; NORT- novel object recognition FST- forced swimming test Y-maze) conducted from 19–21, followed by biochemical analysis hippocampus prefrontal cortex oxidative stress, inflammation, neurotransmitter metabolic enzyme, histopathology. DEN-treated exhibited decreased locomotor activity, spatial memory function antioxidant increased nitration anxiety, depressive-like behaviour, causing histoarchitectural damage hippocampal cortices. treatment (pre- post-DEN exposure) significantly alleviated these neurotoxic, oxidative, effects, reversed histopathological alterations, improved locomotive cognitive functions. In conclusion, demonstrates potent toxicity, likely through enhanced endogenous capacity that mitigates oxido-nitrative damage. These findings suggest organo-selenium -DPDS- promising chemotherapeutic agent alleviating DEN-mediated maintaining brain health.

Language: Английский

Citations

1
Hyaluronic Acid-Based Nanoparticles Loaded with Rutin as Vasculo-Protective Tools against Anthracycline-Induced Endothelial Damages DOI Creative Commons
Carla Serri, Vincenzo Quagliariello, Iriczalli Cruz‐Maya

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 985 - 985

Published: July 25, 2024

Anthracycline-based therapies exert endothelial damages through peroxidation and the production of proinflammatory cytokines, resulting in a high risk cardiovascular complications cancer patients. Hyaluronic acid-based hybrid nanoparticles (LicpHA) are effective pharmacological tools that can target cells deliver drugs or nutraceuticals. This study aimed to prepared characterized novel LicpHA loaded with Rutin (LicpHA Rutin), flavonoid antioxidant anti-inflammatory properties, protect against epirubicin-mediated damages. was using phosphatidylcholine, cholesterol, poloxamers, hyaluronic acid by modified nanoprecipitation technique. The chemical-physical characterization carried out (size, zeta potential, morphology, stability, thermal analysis, encapsulation efficiency). Cytotoxicity studies were performed human exposed epirubicin alone combination Free-Rutin Rutin. Anti-inflammatory intracellular quantification NLRP-3, MyD-88, IL-1β, IL-6, IL17-α, TNF-α, IL-10, IL-4 selective ELISA methods. Morphological via TEM image analysis highlighted heterogeneous population particles non-spherical shapes (circularity equal 0.78 ± 0.14), particle size slightly affected entrapment (the mean diameter varied from 179 4 nm 209 nm). Thermal potential analyses confirmed influence on properties Rutin, mainly indicated decrease surface negative charge (from −35 1 mV −30 0.5 mV). Cellular demonstrated significantly reduced cell death inflammation when compared alone. levels NLRP3, Myd-88, cytokines lower + Rutin-exposed groups (p < 0.001). exerts significant vasculo-protective during exposure anthracyclines. overall picture this pushes towards preclinical clinical models anthracycline-induced vascular

Language: Английский

Citations

0