Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 13, 2023
Abstract
Spinal
cord
injury
(SCI)
induces
oxidative
stress
reactions,
exacerbating
secondary
damage.
Moderating
after
SCI
holds
paramount
significance
for
alleviating
injury.
At
the
same
time,
comprehensive
investigations
into
pathogenesis
of
in
remain
limited.
In
this
study,
we
analyzed
public
datasets
to
identify
differentially
expressed
stress-related
genes
(DEOSRGs)
at
various
post-injury
time
points,
identifying
25
hub
(OSRGs).
We
also
conducted
tests
and
validations
ascertain
temporal
expression
patterns
some
both
tissue
single-cell
levels.
Subsequently,
unveiled
association
between
these
immune
cell
infiltration.
Functional
pathway
enrichment
analyses
were
on
DEOSRGs
distinct
revealing
alterations
enriched
functions
signaling
pathways.
Additionally,
summarized
potential
communication
characteristics
related
among
different
cells
points
level,
along
with
associated
ligand-receptor
pairs.
As
a
subsequent
step,
constructed
mRNA-miRNA/mRNA-miRNA-lncRNA
regulatory
networks
transcription
factors
OSRGs.
Finally,
leveraging
DSigDB
database,
predicted
compounds
capable
inhibiting
eight
genes,
offering
drugs
or
molecules
targeted
interventions
following
SCI.
Consequently,
study
gaining
deeper
insights
mechanisms
timely
Nutritional Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 14
Published: Feb. 28, 2025
Spinal
cord
injury
(SCI)
is
a
major
challenge
in
the
medical
community
because
of
its
difficulty
treatment
and
poor
prognosis.
Extract
ginkgo
biloba
(EGb)
has
been
widely
used
prevention
age-related
neurosensory
disease,
which
considered
to
have
effect
neuroprotection.
We
performed
systematic
review
evaluate
neurobiological
roles
EGb
for
treating
SCI
rats.
Pubmed,
Embase,
Sinomed
China
National
knowledge
Infrastructure
were
searched
from
their
inception
dates
April
2024,
30
articles
included.
The
quality
score
included
studies
ranged
4
7
out
10
points,
all
them
randomization.
It
was
shown
that
after
SCI,
administration
could
significantly
improve
motor
function
(WMD
=
2.09
[1.59,
2.59],
p
<
0.00001).
Subgroup
analysis
concluded
at
doses
10-50
mg/kg
improved
greatest
extent.
In
comparison
with
control
group,
reduce
lipid
peroxidation
inhibit
inflammation
(MDA:
SMD
-1.43
[-5.05,2.20],
0.00001;
iNOS:
WMD
-22.17
[-35.45,
-8.90],
addition,
this
suggested
can
antagonize
inflammation,
oxidative
stress
resistance
apoptosis,
promote
nerve
growth
myelin
loss
on
SCI.
Preclinical
grade
suggests
that,
collectively,
may
be
promising
natural
neuroprotective
agent
unique
advantages
mechanisms
action.
More
clinical
randomized,
blind
controlled
trials
are
also
needed
confirm
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 573 - 573
Published: April 26, 2025
Background:
Spinal
cord
injury
(SCI)
is
a
devastating
neurological
condition
with
limited
therapeutic
options.
Current
clinical
interventions
predominantly
rely
on
prolonged
or
high-dose
pharmacological
regimens,
often
causing
systemic
toxicity
and
adverse
events.
Although
black
phosphorus
nanosheets
(BPNSs)
exhibit
remarkable
reactive
oxygen
species
(ROS)-scavenging
capacity
to
mitigate
oxidative
damage,
their
rapid
degradation
severely
compromises
efficacy.
Methods:
This
study
presents
thermosensitive
hydrogel
gelation
properties
by
incorporating
different
proportions
concentrations
of
sodium
alginate
(SA)
into
chitosan/β-glycerophosphate
(CS/β-GP)
loading
it
BPNS
for
the
treatment
SCI
in
rats.
In
vitro,
physical
composite
were
characterized
cytotoxicity
ROS
scavenging
abilities
assessed
using
PC12
cells;
vivo,
behavioral
tests,
histopathological
analysis,
transcriptomics,
immunohistochemistry,
Western
blotting
performed
explore
effects
mechanisms.
Results:
The
results
demonstrate
that
this
effectively
slows
degradation,
exhibits
high
capacity,
reduces
lipid
peroxidation,
thereby
inhibits
ferroptosis
apoptosis,
offering
neuroprotective
promoting
motor
function
recovery.
Conclusions:
Our
findings
establish
CS/β-GP/SA-BPNS
as
multifunctional
platform
SCI,
synergizing
sustained
drug
release
ROS–ferroptosis–apoptosis
axis
modulation
achieve
neuroprotection
functional
restoration.
strategy
provides
translatable
paradigm
combining
nanotechnology
biomaterial
engineering
neural
repair.
Frontiers in Cellular Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: May 9, 2024
Spinal
cord
injury
(SCI)
disrupts
nerve
pathways
and
affects
sensory,
motor,
autonomic
function.
There
is
currently
no
effective
treatment
for
SCI.
SCI
occurs
within
three
temporal
periods:
acute,
subacute,
chronic.
In
each
period
there
are
different
alterations
in
the
cells,
inflammatory
factors,
signaling
spinal
cord.
Many
biomaterials
have
been
investigated
of
SCI,
including
hydrogels
fiber
scaffolds,
some
progress
has
made
using
multiple
materials.
However,
limitations
when
individual
treatment,
these
can
be
significantly
improved
by
combining
treatments
with
stem
cells.
order
to
better
understand
investigate
new
strategies
its
several
combination
therapies
that
include
materials
combined
drugs,
cytokines,
etc.
summarized
current
review.
Journal of Neurochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 8, 2024
The
impact
of
primary
and
secondary
injuries
spinal
cord
injury
(SCI)
results
in
the
demise
numerous
neurons,
there
is
still
no
efficacious
pharmacological
intervention
for
it.
Recently,
studies
have
shown
that
endoplasmic
reticulum
stress
(ERS)
plays
a
pivotal
role
recovery
neurological
function
after
injury.
As
process
to
cope
with
intracellular
accumulation
misfolded
unfolded
proteins
which
triggers
ERS,
protein
response
(UPR)
an
important
maintaining
homeostasis.
And,
recently
disclosed
small
molecule
AA147,
selectively
activates
activating
transcription
factor
6
(ATF6),
has
promising
effects
several
disease
models.
Thus,
it
seems
feasible
protect
neurons
by
modulating
UPR.
In
this
study,
were
isolated
from
E17-19
C57BL/6J
mouse
embryos
we
observed
AA147
effectively
promoted
survival
alleviated
neuronal
apoptosis
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
vitro.
This
was
evident
through
decrease
proportion
PI-positive
TUNEL-positive
cells,
increase
BCL-2
expression,
expression
BAX
C-caspase3.
in-vivo
experiments,
these
findings
corroborated
TUNEL
staining
immunohistochemistry.
It
also
found
enhanced
three
arms
reduced
CHOP
expression.
Besides,
mitigated
ROS
probably
upregulating
catalase
Furthermore,
models
mice
established
behavioral
experiments
revealed
facilitated
motor
following
SCI.
pharmacologic
activation
ATF6
represents
promise
therapeutic
approach
ameliorate
prognosis
Langmuir,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Antioxidant
play
a
crucial
role
in
the
prevention
and
treatment
of
diseases
associated
with
oxidative
stress.
Curcumin
(CUR),
as
natural
antioxidant,
exhibits
numerous
therapeutic
properties,
including
anti-inflammatory,
antibacterial,
antitumor
activities.
However,
its
limited
bioavailability
poor
water
solubility
hinder
application
an
effective
antioxidant.
In
this
study,
series
mesoporous
silica
nanomaterials
distinct
morphologies,
i.e.,
nanoparticles
(MSN)
nanorods
(MSR)
were
synthesized
by
template–sediment–etching
method.
CUR
was
selected
model
drug
encapsulated
into
these
to
improve
vivo.
The
morphology
size
distribution
MSN
MSR
determined
through
transmission
electron
microscopy
(TEM)
imaging
Zetasizer
analysis.
Fourier
transform
infrared
spectroscopy
(FTIR)
spectra
confirmed
successful
encapsulation
within
nanomaterials.
Furthermore,
CUR-loaded
nanomaterials,
denoted
CUR@MSN
CUR@MSR,
exhibited
excellent
DPPH
ABTS
free
radical
scavenging
activity
vitro.
CUR@MSR
also
obvious
vivo
antioxidant
activity.
This
study
opens
up
new
avenues
for
development
enhanced
antioxidants
utilization
