Essential oils – a review of the natural evolution of applications and some future perspectives

Pharmacia, Journal Year: 2025, Volume and Issue: 72, P. 1 - 12

Published: Jan. 16, 2025

Since ancient times, essential oils (EOs) have been used, thoroughly explored, and regarded as products of great importance for humanity. Currently, EOs represent not only an important part the contemporary pharmaceutical cosmetic industry but are also considered sources novel drug candidates. The article discusses applications in historical terms, current applications, future perspectives. Although there many studies that involve EOs, therapeutic potential is fully investigated. In next decades it highly likely some compounds, isolated from could be included composition candidates with targets neurology, cardiology, or oncology. Moreover, key points development environmentally friendly preservatives pesticides.

Language: Английский

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Multi-biological activity assessment and phytochemical characterization of an aqueous extract of the Cymbopogon citratus grown in Palestine

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 9, 2024

Abstract Background Plants have historically been a rich source of medicinal compounds, with many modern pharmaceuticals derived from botanical origins. In contemporary healthcare, there is resurgence in utilizing substances as recognized agents. This study delved into understanding the phytochemical makeup and multifaceted biological activities an aqueous extract Cymbopogon citratus ( C. ). The investigated were its effect on AMPA receptors, antioxidant capacity, anti-lipase, anti-α-amylase actions, cytotoxicity, antimicrobial properties. Methods received comprehensive investigation, which included composition, assessment anti-lipase properties, evaluation capacity to inhibit α-amylase, analysis impact cell viability, activity. approaches are used clarify complex physiological biochemical characteristics. Results results compelling; receptor kinetics had marked impact, notably GluA2 subunit. Regarding potential, demonstrated potent anti-diabetic IC 50 values 15.13 101.14 µg/mL, respectively. Additionally, it displayed significant inhibitory effects lipase enzyme showed cytotoxicity against Hep3B cancer line, 144.35 148.37 µg/mL. contrast, normal LX-2 line minimal, indicating selectivity. Conclusion shows promising therapeutic findings advocate for further research compounds potential isolation, purification, in-depth pharmacological studies, especially areas like nervous system disorders, diabetes, obesity, combating oxidative stress.

Language: Английский

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Surfactant Mediated Dispersion and stabilization of nano-emulsion droplets enhance antimicrobial activity against multidrug resistant bacteria

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 426, P. 127300 - 127300

Published: March 6, 2025

Language: Английский

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Essential oils to treat insomnia: Clinical-based studies

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 365 - 380

Published: Jan. 1, 2025

Language: Английский

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Therapeutic applications of eucalyptus essential oils

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Eucalyptus essential oils (EEOs) have gained significant attention recently anticipated to their broad range of prospective benefits in various biological applications. They been proven strong antibacterial properties against a variety bacteria, fungi, and viruses. This makes them valuable combating infections supporting overall hygiene. The active compounds present these can help alleviate inflammation, making addressing inflammatory conditions such as arthritis, respiratory ailments, skin disorders. Respiratory health are another prominent aspect EEOs. Inhalation promote clear airways, relieve congestion, ease symptoms like coughs, colds, sinusitis. often utilized inhalation therapies chest rubs. be used topically or massage muscle joint pain. Furthermore, shown potential wound healing. Their antimicrobial activity helps prevent infection, while anti-inflammatory analgesic contribute reducing inflammation pain associated with wounds. In aromatherapy, EEOs renowned for invigorating uplifting qualities, promoting mental clarity, relaxation, stress relief. Overall, hold great promise applications, offering natural versatile approach well-being. Continued research exploration therapeutic will further unveil broaden applications fields.

Language: Английский

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The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Therapeutic Effects of Lavender Oil on Streptozotocin-Induced Diabetes Mellitus and Experimental Thrombosis

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 166 - 166

Published: Jan. 30, 2025

Diabetes mellitus is a metabolic disorder associated with oxidative stress, inflammation, and coagulation disturbances, which contribute to microvascular macrovascular complications. We evaluated the therapeutic effects of lavender oil (Lavandula angustifolia) in streptozotocin (STZ)-induced rat model type 1 diabetes (T1DM) experimentally induced thrombosis. Sixty male Wistar rats were divided into control, thrombosis, diabetes, thrombosis–diabetes, pretreatment groups (100 200 mg/kg body weight [bw]). Lavender exhibited dose-dependent benefits, bw dose leading significant reductions proinflammatory cytokines (e.g., tumor necrosis factor α (TNF-α); regulated upon activation, normal T cell expressed secreted (RANTES); monocyte chemoattractant protein-1 (MCP-1)) along improved glycemic partial restoration C-peptide levels, attenuation matrix metalloproteinase 2 9 (MMP-2 MMP-9) activity (p < 0.0001). Histopathological analyses confirmed its organ-protective antithrombotic effects, including reduced tissue damage, vascular thrombus formation, prolonged bleeding clotting times. Our findings suggest that exhibits antioxidant, anti-inflammatory, hypoglycemic, indicating potential as complementary therapy for managing inflammation T1DM or without

Language: Английский

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Traditional uses, phytochemistry, and pharmacology of Flemingia macrophylla, an important traditional medicinal plant

Published: Feb. 2, 2025

Because of its long history use in traditional medicine, Flemingia macrophylla has attracted a lot attention from the fields phytochemistry and pharmacology. However, comprehensive research data on pharmacological roles have not been found literature. This review combines abundance information regarding application, phytochemical makeup, properties, demonstrating critical role Chinese medicine. Examining past uses many cultural contexts treating gastrointestinal issues to dermatological conditions highlights extraordinary adaptability. article reveals generations-long development as reliable medicine through an examination ethnobotanical records. Its composition is carefully examined this review, which complex array chemicals including flavonoids, alkaloids, terpenoids that are crucial comprehending plant's potential Determining consequences bioactive components plant requires thorough structural clarification. Pharmacological studies demonstrate range actions, antiinflammatory, antioxidant, cardiovascular benefits, consistent with conventional applications. antifungal function particular how useful it against microbial dangers general. Throughout, paper knowledge contemporary pharmacology convergent, emphasizing mutually beneficial interaction between legacy evidence-based treatment. Encapsulating historical significance current relevance integration into modern healthcare practices, compilation could be invaluable resource for researchers, herbalists, practitioners.

Language: Английский

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Composition, Antimicrobial, Anti-Inflammatory, and Potential Neuroprotective Activities of Volatile Oils in Solid Wood Boards from Different Tree Ages of Cryptomeria japonica

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2400 - 2400

Published: March 7, 2025

The wood of Cryptomeria japonica (Japanese cedar or sugi) is widely used in building and adornment. This study aims to identify the composition volatile oils (VOs) extracted from C. solid boards by gas chromatography–mass spectroscopy, investigate their antimicrobial, anti-inflammatory, potential neuroprotective activities. A total 58 organic compounds (VOCs) were identified VOs with tree ages 40, 50, 60 years (VO-40, 60), sandaracopimarinol (13.74–17.59%), ferruginol (10.23–11.29%), abieta-7,13-diene (8.20–13.66%), (+)-δ-cadinene (7.15–9.27%), cis-cubenol (4.36–6.36%), sandaracopimarinal (3.23–6.04%) as major compounds. exhibited antifungal potential, especially VO-50 against Aspergillus fumigatus (MIC = 0.312 mg/mL), VO-60 Gloeophyllum trabeum 1.25 mg/mL). However, weak antibacterial activity > 10 Additionally, (10 μg/mL) anti-inflammatory activities, demonstrating strongest inhibition NO (25.79% reduction), TNF-α (52.24% IL-6 (27.10% reduction) production lipopolysaccharide-induced RAW264.7 cells, while increasing cell viability 70.36% reducing lactate dehydrogenase release 41.10% corticosterone-induced PC12 cells. Correlation docking analyses revealed that sandaracopimarinal, sandaracopimarinol, β-eudesmol, active results demonstrated components not only enhance board’s decay resistance, but also exhibit therapeutic for inflammatory disorders neuropathic diseases.

Language: Английский

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Investigating Bergamot Essential Oil (BEO) Properties: Cytoprotection in Neuronal Cells Exposed to Heavy Metals and Antibacterial Activities

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 400 - 400

Published: March 27, 2025

Bergamot [Citrus × limon (L.) Osbeck, syn. C. bergamia (Risso) Risso & Poit.] is primarily cultivated in the Calabria region of Italy and exploited food perfumery industry. The epicarp its fruit a rich source essential oil (BEO) containing mainly monoterpenes, which are known for their diverse biological activities, including antimicrobial, anti-inflammatory, antiproliferative, neuromodulatory effects. Emerging evidence suggests that oxidative stress plays central role pathogenesis neurodegenerative diseases, particularly Alzheimer’s disease (AD), where it contributes to neuronal dysfunction cell death. Moreover, heavy metal exposure has been identified as key environmental factor exacerbating neurodegeneration AD. This study aimed explore whether BEO could mitigate (Cd2+, Hg2+, Pb2+)-induced neurotoxicity SH-SY5Y cells, model system brain cells. MTT calcein-AM assays were performed examine viability cells after each itself, or combination with BEO, whereas LDH assay was carried out determine effects towards necrotic death induced by metals. Furthermore, DCFH-DA protect from metal-induced stress. also investigated antibacterial properties on different Gram-positive Gram-negative bacterial strains belonging ATCC collection. These results suggest may help counteract damage, Cd2+ toxicity, potentially reducing one risk factors associated Additionally, antimicrobial reinforce relevance preventing infections contribute neuroinflammation

Language: Английский

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