Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2024, Volume and Issue: 42(10), P. 660 - 662
Published: Oct. 1, 2024
Language: Английский
GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: June 11, 2024
Abstract Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) non-pharmacological therapy shows promising results in the treatment or prevention of age-related impairments. The aim this review to compile preclinical and clinical evidence effect PBM during aging healthy pathological conditions, including behavioral analysis neuropsychological assessment, as well brain-related modifications. 37 studies were identified by searching PubMed, Scopus, PsycInfo databases. Most use wavelengths 800, 810, 1064 nm but intensity days application highly variable. In animal studies, it has been shown improvements spatial memory, episodic-like social while different have found recognition memory. Locomotor activity improved Parkinson disease models. aged humans, outlined working inhibition, lexical/semantic access, general cognition was mainly enhanced on Alzheimer mild impairment. Anxiety assessment scarce mixed results. As for brain activity, outline effects reversing metabolic alterations enhancing mitochondrial function, evidenced restored CCO ATP levels. Additionally, demonstrated neuroprotective, anti-inflammatory, immunomodulatory hemodynamic effects. findings suggest holds promise non-invasive intervention modulation functional reorganization. It necessary develop standardized protocols correct, beneficial, homogeneous PBM.
Language: Английский
Citations
7
Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 211 - 228
Published: Nov. 27, 2024
Noninvasive brain stimulation techniques have emerged as a promising therapeutic option for various central nervous system demyelinating diseases. Demyelinating diseases represent group of pathological conditions that impact the or peripheral system. They are characterized by damage to loss myelin sheath surrounding nerve fibers. This sheaths disrupts signal transmission, leading wide range signs and symptoms associated with neurological impairment. Treatment usually aligns specific underlying cause. can affect neuronal electrical activity glial cell function, suggesting potential intervention. In this narrative review, we explore noninvasive treatment disorders. techniques, including transcranial magnetic stimulation, focused ultrasound optogenetic low-intensity pulsed ultrasound, photobiomodulation, been shown potentially intervene in affecting cells function. addition, review summarizes applications mechanisms how these promote regeneration improve disease prognosis. also research advances multiple sclerosis, acute disseminated encephalomyelitis, progressive multifocal leukoencephalopathy, neuromyelitis optical spectrum disorder. promoting oligodendrocyte proliferation differentiation, enhancing regeneration, modulating immune responses. Although disorders, their use treating remains challenging. For example, is relatively new technique advantages high spatial resolution ability stimulate deep structures, but its safety efficacy clinical need be further investigated. Optogenetic offers highly precise neuromodulation, feasibility practice limited technical ethical constraints. Overall, significant diseases, needed optimize parameters, efficacy, gain insight into mechanism action. With continuous development technology in-depth trials, expected become an effective provide options such patients.
Language: Английский
Citations
3
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: May 9, 2025
Mania is a mind disorder with heightened emotions, etc. Amphetamine (AMPH), drug central nervous system excitatory effects, can disrupt neurotransmitter release and metabolism, causing mania. AMPH-induced animal models of mania show increased risk reward-seeking behaviors excessive locomotion like patients, verifiable by tests Elevated Plus Maze (EPM). It also impacts balance in different brain regions, aligning the imbalance patients. Multiple signaling pathways including extracellular regulated protein kinases others are involved, their altered activities link to symptoms. In model, regions frontal cortex have oxidative stress inflammatory response. Moreover, AMPH changes neurotrophin levels, potentially neuronal damage cognitive impairment. summary, model crucial for studying mania’s pathogenesis. However, further in-depth studies on regulation, pathway intervention, neurotrophic factors needed develop more effective personalized treatment plans.
Language: Английский
Citations
0
Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)
Published: Nov. 5, 2024
Abstract Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the protective effects of vitamin D3 (Vit. D3) in countering oxidative stress, neuroinflammation apoptosis induced by sodium arsenite (SA) cerebral cortex rats. Male Wistar rats were subjected to a daily oral administration (NaAsO2, SA) at dosage 5 mg/kg, along 500 IU/kg Vit. D3, combination both substances for four weeks. results indicated that effectively mitigated SA-induced increase stress markers, thiobarbituric acid reactive (TBARS) nitric oxide (NO), decrease antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, glutathione peroxidase; GPx), as well pro-inflammatory markers including, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), amyloid-beta (Aβ)1–42. Furthermore, reversed alterations neurochemicals acetylcholinesterase (AchE), monoamine oxidase (MAO), dopamine (DA), acetylcholine (Ach) ameliorated histopathological changes cortex. Moreover, immunohistochemical analyses revealed reduced overexpression cysteine aspartate-specific protease-3 (caspase-3) glial fibrillary acidic protein (GFAP) male Consequently, co-administration can protect against neurotoxicity, primarily through its antioxidant, anti-inflammatory, anti-apoptotic, anti-astrogliosis effects.
Language: Английский
Citations
1
Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2024, Volume and Issue: 42(10), P. 660 - 662
Published: Oct. 1, 2024
Language: Английский
Citations
0