COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy
European Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
54(10)
Published: Aug. 8, 2024
Abstract
In
this
narrative
review,
we
assess
the
pathophysiology
of
severe
adverse
events
that
presented
after
vaccination
with
DNA
and
mRNA
vaccines
against
COVID‐19.
The
focus
is
on
perspective
an
undersulfated
degraded
glycocalyx,
considering
its
impact
immunomodulation,
inflammatory
responses,
coagulation
oxidative
stress.
paper
explores
various
factors
lead
to
glutathione
inorganic
sulfate
depletion
their
subsequent
effect
glycocalyx
sulfation
other
metabolites,
including
hormones.
Components
COVID‐19
vaccines,
such
as
material,
spike
protein
antigen
lipid
nanoparticles,
are
involved
in
possible
cytotoxic
effects.
common
thread
connecting
these
endotheliopathy
or
degradation,
caused
by
depleted
levels,
shear
stress
from
circulating
aggregation
formation
coronas;
leading
imbalanced
immune
responses
chronic
release
pro‐inflammatory
cytokines,
ultimately
resulting
systemic
response
syndrome.
By
understanding
underlying
events,
better
treatment
options
can
be
explored.
Language: Английский
Transplacental transmission of mRNA injections confirmed: does this evidence by Hanna and colleagues support their proposition as a promising prenatal gene therapy?
Published: Aug. 25, 2024
A
recent
study
by
Hanna
and
collaborators
assessed
the
presence
of
COVID-19
mRNA
productsin
placenta
umbilical
cord
blood
following
maternal
“vaccination”
during
human
pregnancy.Their
analysis
2
pregnant
women
revealed
that
genetic
injections
was
detected
inboth
placentas.
Spike
protein
expression
confirmed
in
one
them.
Furthermore,the
engineered
mother,
wherethose
samples
were
available
for
analysis.
They
also
found
integrity
injected
varied
across
samples,
but
overall,
a
substantial
or
even
overwhelming
majority
consisted
non-integrous
species.
The
authors
provide
several
theoretical
reasons
they
believe
explain
their
experiential
observations.
Based
on
results
shifting
aim,
indicate
benefits
suggest
related
gene
therapies,
particularly
mRNA-based
treatments,
may
have
great
promise
as
prenatal
therapy.
This
article
analyses
findings
interpretations
identifies
gaps
inconsistencies
explanations.
It
provides
short
synopsis
update
known
problems
with
outlines
major
pitfalls
unknowns
underlying
thepromised
intended
therapy
applications.
Language: Английский
Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC
Frontiers in Cellular Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Dec. 18, 2024
The
persistence
or
emergence
of
long-term
symptoms
following
resolution
primary
SARS-CoV-2
infection
is
referred
to
as
long
COVID
post-acute
sequelae
COVID-19
(PASC).
PASC
predominantly
affects
the
cardiovascular,
neurological,
respiratory,
gastrointestinal,
reproductive,
and
immune
systems.
Among
these,
central
nervous
system
(CNS)
significantly
impacted,
leading
a
spectrum
symptoms,
including
fatigue,
headaches,
brain
fog,
cognitive
impairment,
anosmia,
hypogeusia,
neuropsychiatric
peripheral
neuropathy
(neuro-PASC).
However,
risk
factors
pathogenic
mechanisms
responsible
for
neuro-PASC
remain
unclear.
This
review
hypothesis
discusses
hypotheses
regarding
pathophysiological
involved
in
COVID/PASC,
focusing
on
neuro-PASC.
We
propose
vascular
dysfunction
mediated
by
activation
astrocytes
pericytes
followed
blood-brain
barrier
(BBB)
disruption
underlying
neurological
manifestations.
Additionally,
we
provide
insights
into
role
spike
protein
at
interface.
Finally,
explore
potential
initiated
interaction
between
cellular
receptors
endothelial
tissue
levels.
Language: Английский